Gpr37 Gene Summary [Mouse]
Enables PDZ domain binding activity. Involved in cellular response to reactive oxygen species; dendrite development; and positive regulation of MAPK cascade. Acts upstream of or within dopamine biosynthetic process; locomotion involved in locomotory behavior; and positive regulation of dopamine metabolic process. Is active in cell surface and synapse. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and immune system. Orthologous to human GPR37 (G protein-coupled receptor 37). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gpr37 |
| Official Name | G protein-coupled receptor 37 [Source:MGI Symbol;Acc:MGI:1313297] |
| Ensembl ID | ENSMUSG00000039904 |
| Bio databases IDs | |
| Aliases | G protein-coupled receptor 37 |
| Synonyms | EDNRBL, G protein-coupled receptor 37, hET(B)R-LP, PAELR |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gpr37 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- G-protein coupled peptide receptor
- ubiquitin protein ligase binding
- peptide binding
- Cholecystokinin A receptor, N-terminal
- Hsp70 protein binding
- neuropeptide receptor
- heat shock protein binding
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- PDZ-domain binding
- neuropeptide binding
- 7 transmembrane receptor (rhodopsin family)
Pathways
Biological processes and signaling networks where the Gpr37 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Adrenomedullin signaling pathway
- Breast Cancer Regulation by Stathmin1
- Cellular Effects of Sildenafil (Viagra)
- CREB Signaling in Neurons
- FAK Signaling
- G-Protein Coupled Receptor Signaling
- GABA Receptor Signaling
- Gustation Pathway
- Neuropathic Pain Signaling In Dorsal Horn Neurons
- Parkinson's Signaling
- Phagosome Formation
- Serotonin Receptor Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- Huntington disease
- schizophrenia
- lung squamous cell carcinoma
- squamous cell lung cancer
- hemangioma
- angiomatosis
- autosomal recessive juvenile parkinsonism
- non-small cell lung cancer
role in cell
- apoptosis
- expression in
- phosphorylation in
- migration
- cell death
- degeneration
- activation
- function
- glycolysis in
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- perinuclear region
- cellular membrane
- Endoplasmic Reticulum
- presynaptic membrane
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gpr37 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
- dopamine biosynthetic process
- locomotion involved in locomotory behavior
- neuropeptide signaling pathway
- G-protein coupled receptor signaling pathway
- positive regulation of MAPK cascade
- cellular response to reactive oxygen species
- positive regulation of dopamine metabolic process
- dendrite development
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- dendrite
- ubiquitin ligase complex
- cytoplasm
- receptor complex
- endoplasmic reticulum
- synapse
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- heat shock protein binding
- G-protein coupled receptor activity
- G-protein coupled peptide receptor activity
- neuropeptide binding
- protein binding
- ubiquitin protein ligase binding
- neuropeptide receptor activity
- PDZ domain binding
- peptide binding
- Hsp70 protein binding