St3gal1 Gene Summary [Mouse]
Enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity. Involved in several processes, including ganglioside biosynthetic process via lactosylceramide; memory B cell differentiation; and negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process. Acts upstream of or within protein glycosylation and protein phosphorylation. Predicted to be located in Golgi medial cisterna membrane; Golgi trans cisterna membrane; and trans-Golgi network membrane. Predicted to be active in membrane. Is expressed in several structures, including alimentary system; ear; hemolymphoid system; integumental system; and nervous system. Orthologous to human ST3GAL1 (ST3 beta-galactoside alpha-2,3-sialyltransferase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | St3gal1 |
| Official Name | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 [Source:MGI Symbol;Acc:MGI:98304] |
| Ensembl ID | ENSMUSG00000013846 |
| Bio databases IDs | |
| Aliases | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 |
| Synonyms | 5330418N22Rik, AI467004, Gal-NAc6S, LOC286167, SIALYLTRANSFERASE 4A, Siat4, SIAT4A, SIATFL, ST3 beta-galactoside alpha-2,3-sialyltransferase 1, ST3GalA, ST3GalA.1, ST3GalI, ST3GalIA, ST3GalIA,1, ST3O, ST3 β-galactoside α-2,3-sialyltransferase 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse St3gal1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glycosyltransferase family 29 (sialyltransferase)
- beta-galactoside alpha-2,3-sialyltransferase
- glycosyltransferase family 29
- sialyltransferase
- enzyme
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- androgenic alopecia
- aortic valve calcification
- vertigo
- frontal fibrosing alopecia
- squamous-cell carcinoma
- squamous cell cancer
- Turner syndrome
- Klinefelter syndrome
regulates
- O-glycan
- keratan sulfate
- beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-R-group
- NFkB (complex)
- GCNT1
role in cell
- quantity
- apoptosis
- invasion by
- activation in
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- Golgi membrane
- trans Golgi network
- Golgi cisternae
- trans Golgi cisternae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse St3gal1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein modification process
- ganglioside biosynthetic process via lactosylceramide
- viral protein processing
- N-acetylneuraminate metabolic process
- memory B cell differentiation
- protein glycosylation
- protein N-linked glycosylation
- O-glycan processing
- keratan sulfate biosynthetic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- membrane
- Golgi membrane
- trans-Golgi network membrane
Molecular Function
What the gene product does at the molecular level
- monosialoganglioside sialyltransferase activity
- beta-galactoside (CMP) alpha-2,3-sialyltransferase activity
- sialyltransferase activity