Gcnt1 Gene Summary [Mouse]
Enables beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity. Involved in core 2 O-glycan biosynthetic process and positive regulation of leukocyte tethering or rolling. Acts upstream of or within kidney morphogenesis and tissue morphogenesis. Predicted to be located in Golgi cisterna; extracellular space; and trans-Golgi network. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; sensory organ; and skeleton. Orthologous to human GCNT1 (glucosaminyl (N-acetyl) transferase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gcnt1 |
| Official Name | glucosaminyl (N-acetyl) transferase 1, core 2 [Source:MGI Symbol;Acc:MGI:95676] |
| Ensembl ID | ENSMUSG00000038843 |
| Bio databases IDs | |
| Aliases | glucosaminyl (N-acetyl) transferase 1, core 2 |
| Synonyms | 5630400D21Rik, B130048E03, beta-1,6-N-ACETYLGLUCOSAMINYLTRANSFERASE, C2 GlcNAcT, C2GNT, C2GNT1, C2GNT-L, core 2 GlcNAc-T, core 2 β 1,6 n acetylglucosaminyltransferase leukocyte type, G6NT, glucosaminyl (N-acetyl) transferase 1, glucosaminyl (N-acetyl) transferase 1, core 2, IGnT, LOC635918, NACGT2, NAGCT2, β-1,6-N-ACETYLGLUCOSAMINYLTRANSFERASE |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gcnt1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Core-2/I-Branching enzyme
- beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic kidney disease
- delayed hypersensitive reaction
- preeclampsia
role in cell
- binding in
- cell death
- proliferation
- quantity
- differentiation
- number
- binding
- abnormal morphology
- cell rolling
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- cellular membrane
- medial face of the Golgi apparatus
- cis face of the Golgi apparatus
- Golgi membrane
- trans Golgi network
- Golgi cisternae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gcnt1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell adhesion molecule production
- tissue morphogenesis
- response to insulin stimulus
- kidney morphogenesis
- glycoprotein biosynthetic process
- leukocyte tethering or rolling
- O-glycan processing
- O-glycan processing, core 2
Cellular Component
Where in the cell the gene product is active
- extracellular space
- trans-Golgi network
- membrane
- Golgi membrane
- Golgi cisterna
Molecular Function
What the gene product does at the molecular level
- protein binding
- beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity