Hivep2 Gene Summary [Mouse]
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within DNA-templated transcription and signal transduction. Predicted to be located in nucleoplasm. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; brain; branchial arch; embryo mesenchyme; and urinary system. Used to study intellectual disability and schizophrenia. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 43. Orthologous to human HIVEP2 (HIVEP zinc finger 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hivep2 |
| Official Name | human immunodeficiency virus type I enhancer binding protein 2 [Source:MGI Symbol;Acc:MGI:1338076] |
| Ensembl ID | ENSMUSG00000015501 |
| Bio databases IDs | |
| Aliases | human immunodeficiency virus type I enhancer binding protein 2 |
| Synonyms | Gm20114, HIVEP zinc finger 2, human immunodeficiency virus type I enhancer binding protein 2, LOC105369170, MBP-2, MIBP-1, MRD43, Myc intron binding protein 1, Schnurri-2, SHN2, ZAS2, ZNF40B |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hivep2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- nucleic acid binding
- double-stranded DNA binding
- Zinc-finger double domain
- metal ion binding
- protein binding
- sequence-specific DNA binding
- transcription factor activity
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- autosomal dominant mental retardation type 43
- hereditary disorder
- metabolic syndrome X
- COVID-19
- non-insulin-dependent diabetes mellitus
- cardiovascular disorder
- asthma
- head and neck neoplasia
- bipolar disorder
- mental retardation
role in cell
- number
- mineralization
- differentiation
- development
- function
- abnormal morphology
- autophagy in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hivep2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity