Nfatc1 Gene Summary [Mouse]
Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and mitogen-activated protein kinase p38 binding activity. Involved in heart development and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including circulatory system development; leukocyte differentiation; and negative regulation of cell population proliferation. Located in cytoplasm and nucleus. Part of transcription regulator complex. Is expressed in several structures, including eye; genitourinary system; heart; hemolymphoid system; and limb mesenchyme. Human ortholog(s) of this gene implicated in congenital heart disease and ventricular septal defect. Orthologous to human NFATC1 (nuclear factor of activated T cells 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nfatc1 |
| Official Name | nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1 [Source:MGI Symbol;Acc:MGI:102469] |
| Ensembl ID | ENSMUSG00000033016 |
| Bio databases IDs | |
| Aliases | nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1 |
| Synonyms | 2210017P03Rik, NFAT2, NF-ATC, NF-ATc1.2, Nfatcb, nuclear factor of activated T-cells 1, nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nfatc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SP repeat domain
- transcription regulator
- regulatory domain
- Sumoylation motif
- Rel homology dimerization domain
- transcription activation domain
- chromatin binding
- transcription factor binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- serine-rich region
- FK506 binding
- Pka phosphorylation site
- Gsk3 phosphorylation site
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- DNA binding domain
- nucleic acid binding
- IPT
- mitogen-activated protein kinase p38 binding
- protein binding
- calcineurin-binding domain
- sequence-specific DNA binding
- DNA binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- protein phosphatase 2B binding
- double-stranded DNA binding
- IPT/TIG domain
- N-terminal sub-domain of the Rel homology domain (RHD)
- transcription factor activity
Pathways
Biological processes and signaling networks where the Nfatc1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- April Mediated Signaling
- B Cell Activating Factor Signaling
- Calcium Signaling
- Ephrin A Signaling
- ERK/MAPK Signaling
- fMLP Signaling in Neutrophils
- Glucocorticoid Receptor Signaling
- Gαq Signaling
- IL-12 Signaling and Production in Macrophages
- IL-7 Signaling Pathway
- Natural Killer Cell Signaling
- Netrin Signaling
- Nur77 Signaling in T Lymphocytes
- PI3K Signaling in B Lymphocytes
- PKCθ Signaling in T Lymphocytes
- Protein Kinase A Signaling
- RANK Signaling in Osteoclasts
- Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- Systemic Lupus Erythematosus Signaling
- Th1 and Th2 Activation Pathway
- Th1 Pathway
- Th17 Activation Pathway
- Wnt/Ca+ pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- atrial fibrillation
- cancer
- edema
- diabetes mellitus
- plasma cell myeloma
- bleeding
- hyperplasia
- breast cancer
- prostate cancer
role in cell
- phosphorylation in
- proliferation
- growth
- expression in
- binding in
- activation in
- cell death
- cellular infiltration by
- number
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- perinuclear region
- cytosol
- sarcoplasm
- nucleoplasm
- nuclear bodies
- Z line
- chromatin
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nfatc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- calcineurin-NFAT signaling cascade
- response to muscle activity
- aortic valve morphogenesis
- pulmonary valve morphogenesis
- positive regulation of transcription from RNA polymerase II promoter
- skeletal muscle adaptation
- regulation of transcription from RNA polymerase II promoter
- cellular response to transforming growth factor beta stimulus
- wound healing
- positive regulation of transcription, DNA-dependent
- cellular response to tumor necrosis factor
- cytokine production
- positive regulation of DNA biosynthetic process
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- nucleus
- nuclear body
- perinuclear region of cytoplasm
- sarcoplasm
- cytoplasm
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- nucleic acid binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- mitogen-activated protein kinase p38 binding
- FK506 binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- transcription factor binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity
- transcription coactivator binding