HIVEP2 Gene Summary [Human]
This gene encodes a member of a family of closely related, large, zinc finger-containing transcription factors. The encoded protein regulates transcription by binding to regulatory regions of various cellular and viral genes that maybe involved in growth, development and metastasis. The protein contains the ZAS domain comprised of two widely separated regions of zinc finger motifs, a stretch of highly acidic amino acids and a serine/threonine-rich sequence. [provided by RefSeq, Nov 2012]
Details
| Type | Protein Coding |
| Official Symbol | HIVEP2 |
| Official Name | HIVEP zinc finger 2 [Source:HGNC Symbol;Acc:HGNC:4921] |
| Ensembl ID | ENSG00000010818 |
| Bio databases IDs | |
| Aliases | HIVEP zinc finger 2, c-myc intron binding protein 1 |
| Synonyms | Gm20114, HIVEP zinc finger 2, human immunodeficiency virus type I enhancer binding protein 2, LOC105369170, MBP-2, MIBP-1, MRD43, Myc intron binding protein 1, Schnurri-2, SHN2, ZAS2, ZNF40B |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HIVEP2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- nucleic acid binding
- double-stranded DNA binding
- Zinc-finger double domain
- metal ion binding
- protein binding
- sequence-specific DNA binding
- transcription factor activity
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- autosomal dominant mental retardation type 43
- hereditary disorder
- metabolic syndrome X
- COVID-19
- non-insulin-dependent diabetes mellitus
- cardiovascular disorder
- asthma
- head and neck neoplasia
- bipolar disorder
- mental retardation
role in cell
- number
- mineralization
- differentiation
- development
- function
- abnormal morphology
- autophagy in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HIVEP2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity