Zfp318 Gene Summary [Mouse]

Enables protein heterodimerization activity and protein homodimerization activity. Involved in negative regulation of DNA-templated transcription and positive regulation of DNA-templated transcription. Located in nucleus. Is expressed in central nervous system; early conceptus; reproductive system; and urinary system. Orthologous to human ZNF318 (zinc finger protein 318). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Zfp318
Official Name
zinc finger protein 318 [Source:MGI Symbol;Acc:MGI:1889348]
Ensembl ID
ENSMUSG00000015597
Bio databases IDs NCBI: 57908 Ensembl: ENSMUSG00000015597
Aliases zinc finger protein 318
Synonyms 2610034E08Rik, D530032D06Rik, HRIHFB2436, LOC683524, TZF, ZFP318, zinc finger protein 318
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zfp318 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • protein homodimerization
  • Herpesvirus leader protein
  • U1 zinc finger
  • Extensin-like region
  • protein binding
  • protein heterodimerization

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • hypertension
  • hearing loss
  • gout
  • age-related hearing loss
  • tinnitus
regulated by
regulates
  • IgD
  • IgM
  • CD23
role in cell
  • expression in
  • development
  • number
  • frequency

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • cytosol
  • nucleoplasm

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Zfp318 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • meiotic cell cycle
  • negative regulation of transcription, DNA-dependent
  • positive regulation of transcription, DNA-dependent

Cellular Component

Where in the cell the gene product is active
  • cytosol
  • nucleoplasm

Molecular Function

What the gene product does at the molecular level
  • nucleic acid binding
  • zinc ion binding
  • protein homodimerization activity

Gene-Specific Assays for Results You Can Trust

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