Liph Gene Summary [Mouse]
Predicted to enable heparin binding activity and phospholipase activity. Predicted to be involved in lipid catabolic process. Predicted to be located in extracellular region and plasma membrane. Predicted to be active in extracellular space. Is expressed in several structures, including anal canal; epidermis; genitourinary system; gut; and hippocampus. Human ortholog(s) of this gene implicated in hypotrichosis 7. Orthologous to human LIPH (lipase H). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Liph |
| Official Name | lipase, member H [Source:MGI Symbol;Acc:MGI:2388029] |
| Ensembl ID | ENSMUSG00000044626 |
| Bio databases IDs | |
| Aliases | lipase, member H |
| Synonyms | AH, ARWH2, C130037N08Rik, D16Wsu119e, H06, HYPT7, LAH2, lipase H, lipase, member H, lpd1, lpd2, LPDLR, mPA-PLA1, P3, PLA1B |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Liph often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- alpha/beta hydrolases
- lipase
- enzyme
- protein binding
- heparin binding
- phospholipase
Pathways
Biological processes and signaling networks where the Liph gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- hereditary hypotrichosis simplex
- thyroid carcinoma
- epithelial thyroid cancer
- autosomal recessive woolly hair 2
- organismal death
- hypotrichosis type 7
- colon cancer
- diabetes mellitus
- pancreatic ductal adenocarcinoma
role in cell
- proliferation
- expression in
- phosphorylation in
- colony formation by
- glycolysis in
- production
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Plasma Membrane
- detergent insoluble microdomains
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Liph gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lipid catabolic process
- phosphatidic acid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- extracellular space
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- heparin binding
- carboxylic ester hydrolase activity
- phospholipase activity