Smug1 Gene Summary [Mouse]
Predicted to enable DNA N-glycosylase activity; identical protein binding activity; and single-stranded DNA binding activity. Predicted to be involved in base-excision repair. Predicted to be located in cytosol; fibrillar center; and nucleoplasm. Is expressed in several structures, including lower urogenital tract; palatal shelf; reproductive system; retina layer; and urethra epithelium. Orthologous to human SMUG1 (single-strand-selective monofunctional uracil-DNA glycosylase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Smug1 |
| Official Name | single-strand selective monofunctional uracil DNA glycosylase [Source:MGI Symbol;Acc:MGI:1918976] |
| Ensembl ID | ENSMUSG00000036061 |
| Bio databases IDs | |
| Aliases | single-strand selective monofunctional uracil DNA glycosylase |
| Synonyms | 1200013B09Rik, A930006H09Rik, FDG, HMUDG, LOC107984513, single-strand selective monofunctional uracil DNA glycosylase, single-strand-selective monofunctional uracil-DNA glycosylase 1, UNG3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Smug1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DNA N-glycosylase
- oxidized base lesion DNA N-glycosylase
- single-stranded DNA binding
- single-strand selective uracil DNA N-glycosylase
- pyrimidine-specific oxidized base lesion DNA N-glycosylase
- uracil DNA N-glycosylase
- enzyme
- protein binding
- identical protein binding
- uracil-DNA glycosylases (UDG) and related enzymes
Pathways
Biological processes and signaling networks where the Smug1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- coronary artery disease
- non-insulin-dependent diabetes mellitus
- idiopathic scoliosis
- myocardial infarction
regulates
- RNR
- 5-hydroxymethyluridine
- HPRT1
- nucleotide
- 5-hydroxymethyluracil
- APEX1
role in cell
- cell viability
- survival
- accumulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- fibrillar center
- Cytoplasm
- cytosol
- nucleoplasm
- nucleoli
- Cajal bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Smug1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- base-excision repair
- depyrimidination
Cellular Component
Where in the cell the gene product is active
- cytosol
- nucleolus
- fibrillar center
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- uracil DNA N-glycosylase activity
- oxidized pyrimidine base lesion DNA N-glycosylase activity
- single-strand selective uracil DNA N-glycosylase activity
- DNA N-glycosylase activity