Steap2 Gene Summary [Mouse]
Enables cupric reductase (NADH) activity and ferric-chelate reductase (NADPH) activity. Acts upstream of or within transition metal ion transport. Located in endosome and plasma membrane. Is expressed in several structures, including brain; gut; metanephros; reproductive system; and respiratory system. Orthologous to human STEAP2 (STEAP2 metalloreductase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Steap2 |
| Official Name | six transmembrane epithelial antigen of prostate 2 [Source:MGI Symbol;Acc:MGI:1921301] |
| Ensembl ID | ENSMUSG00000015653 |
| Bio databases IDs | |
| Aliases | six transmembrane epithelial antigen of prostate 2 |
| Synonyms | 4921538B17RIK, AW045895, IPCA-1, PCANAP1, PUMPCn, six transmembrane epithelial antigen of prostate 2, STAMP1, STAMP2, STEAP2 metalloreductase, STMP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Steap2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- cupric reductase
- ferric-chelate reductase
- metal ion oxidising:NAD or NADP oxidoreductase
- NADP oxidoreductase coenzyme F420-dependent
- Cytochrome_b_N
- enzyme
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- impaired glucose tolerance
- metabolic disorder
- non-insulin-dependent diabetes mellitus
- dyslipidemia
- hepatic steatosis
- hyperglycemia
- major depression
- insulin resistance
- castration refractory prostate cancer
regulated by
- CD3 (complex)
- decitabine
- AHR
- alpha catenin
- STMP1
- testosterone
- dehydroisoandrosterone
- trichostatin A
- SP2509
- tazemetostat
role in cell
- differentiation
- phosphorylation in
- expression in
- growth
- colony formation
- mitochondrial respiration in
- inflammatory response
- autophagic flux in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- perinuclear region
- endosomes
- Golgi Apparatus
- cytosol
- Golgi membrane
- trans Golgi network
- early endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Steap2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulated secretory pathway
- Golgi to plasma membrane transport
- endocytosis
- response to hormone stimulus
- copper ion import
Cellular Component
Where in the cell the gene product is active
- early endosome
- endosome
- trans-Golgi network transport vesicle
- cytosol
- endosome membrane
- Golgi membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ferric-chelate reductase (NADPH) activity
- metal ion binding
- cupric reductase activity