STEAP2 Gene Summary [Human]
This gene is a member of the STEAP family and encodes a multi-pass membrane protein that localizes to the Golgi complex, the plasma membrane, and the vesicular tubular structures in the cytosol. A highly similar protein in mouse has both ferrireductase and cupric reductase activity, and stimulates the cellular uptake of both iron and copper in vitro. Increased transcriptional expression of the human gene is associated with prostate cancer progression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | STEAP2 |
| Official Name | STEAP2 metalloreductase [Source:HGNC Symbol;Acc:HGNC:17885] |
| Ensembl ID | ENSG00000157214 |
| Bio databases IDs | |
| Aliases | STEAP2 metalloreductase |
| Synonyms | 4921538B17RIK, AW045895, IPCA-1, PCANAP1, PUMPCn, six transmembrane epithelial antigen of prostate 2, STAMP1, STAMP2, STEAP2 metalloreductase, STMP |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human STEAP2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- cupric reductase
- ferric-chelate reductase
- metal ion oxidising:NAD or NADP oxidoreductase
- NADP oxidoreductase coenzyme F420-dependent
- Cytochrome_b_N
- enzyme
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- impaired glucose tolerance
- metabolic disorder
- non-insulin-dependent diabetes mellitus
- dyslipidemia
- hepatic steatosis
- hyperglycemia
- major depression
- insulin resistance
- castration refractory prostate cancer
role in cell
- differentiation
- phosphorylation in
- expression in
- growth
- colony formation
- mitochondrial respiration in
- inflammatory response
- autophagic flux in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- perinuclear region
- endosomes
- Golgi Apparatus
- cytosol
- Golgi membrane
- trans Golgi network
- early endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human STEAP2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulated secretory pathway
- Golgi to plasma membrane transport
- endocytosis
- response to hormone stimulus
- copper ion import
Cellular Component
Where in the cell the gene product is active
- early endosome
- endosome
- trans-Golgi network transport vesicle
- cytosol
- endosome membrane
- Golgi membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ferric-chelate reductase (NADPH) activity
- metal ion binding
- cupric reductase activity