Plekho1 Gene Summary [Mouse]
Acts upstream of or within several processes, including lamellipodium morphogenesis; myoblast fusion; and myoblast migration. Located in muscle cell projection membrane and ruffle membrane. Orthologous to human PLEKHO1 (pleckstrin homology domain containing O1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Plekho1 |
| Official Name | pleckstrin homology domain containing, family O member 1 [Source:MGI Symbol;Acc:MGI:1914470] |
| Ensembl ID | ENSMUSG00000015745 |
| Bio databases IDs | |
| Aliases | pleckstrin homology domain containing, family O member 1 |
| Synonyms | 2810052M02RIK, CK2 INTERACTING protein 1, CKIP-1, JBP, Jza2, JZA-20, OC120, pleckstrin homology domain containing, family O member 1, pleckstrin homology domain containing O1, RGD1311487 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Plekho1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PH domain
- leucine zipper domain
- protein binding
- Pleckstrin homology-like domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- bipolar disorder
- androgenic alopecia
role in cell
- migration
- proliferation
- binding in
- differentiation
- formation
- apoptosis
- activation
- function
- osteogenesis
- morphogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell periphery
- Nucleus
- membrane ruffles
- cellular protrusions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Plekho1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- myoblast migration
- lamellipodium morphogenesis
- myoblast fusion
Cellular Component
Where in the cell the gene product is active
- nucleus
- muscle cell projection membrane
- cytoplasm
- ruffle membrane
Molecular Function
What the gene product does at the molecular level
- protein binding