Noc2l Gene Summary [Mouse]
Predicted to enable several functions, including nucleosome binding activity; p53 binding activity; and transcription corepressor activity. Predicted to be involved in several processes, including cellular response to UV; negative regulation of apoptotic process; and negative regulation of transcription by RNA polymerase II. Predicted to be located in chromosome; cytosol; and nucleus. Predicted to be part of Noc1p-Noc2p complex; Noc2p-Noc3p complex; and nucleosome. Predicted to be active in nucleolus and nucleoplasm. Is expressed in several structures, including connective tissue; eye; genitourinary system; gut; and hemolymphoid system gland. Orthologous to human NOC2L (NOC2 like nucleolar associated transcriptional repressor). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Retained Intron |
| Official Symbol | Noc2l |
| Official Name | NOC2 like nucleolar associated transcriptional repressor [Source:MGI Symbol;Acc:MGI:1931051] |
| Ensembl ID | ENSMUSG00000095567 |
| Bio databases IDs | |
| Aliases | NOC2 like nucleolar associated transcriptional repressor |
| Synonyms | AF155546, Gm3811, Inhibitor of histone deacetyltransferase, NET15, NET7, NIR, NOC2-like nucleolar associated transcriptional repressor, PPP1R112, RGD1309387 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Noc2l often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- transcription regulator
- binding protein
- Noc2p family
- transcription co-repressor
- transcription factor binding
- chromatin binding
- p53 binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- preeclampsia
- pancreatic carcinoma
- pancreatic epithelial cancer
role in cell
- expression in
- apoptosis
- proliferation
- processing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- cytosol
- chromosome
- nucleosomes
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Noc2l gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- positive regulation of gene expression, epigenetic
- ribosomal large subunit biogenesis
- apoptotic process
- cellular response to UV
- negative regulation of B cell apoptotic process
- negative regulation of intrinsic apoptotic signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- Noc2p-Noc3p complex
- Noc1p-Noc2p complex
- cytosol
- chromosome
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- transcription corepressor activity
- histone binding
- nucleosome binding
- chromatin binding