Ftsj3 Gene Summary [Mouse]
Predicted to enable rRNA (guanine) methyltransferase activity and rRNA (uridine-2'-O-)-methyltransferase activity. Predicted to be involved in maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); and rRNA methylation. Predicted to be located in chromosome and nucleoplasm. Predicted to be part of preribosome, large subunit precursor. Predicted to be active in nucleolus. Is expressed in several structures, including central nervous system; gonad; liver; retina; and spleen. Orthologous to human FTSJ3 (FtsJ RNA 2'-O-methyltransferase 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ftsj3 |
| Official Name | FtsJ RNA methyltransferase homolog 3 (E. coli) [Source:MGI Symbol;Acc:MGI:1860295] |
| Ensembl ID | ENSMUSG00000020706 |
| Bio databases IDs | |
| Aliases | FtsJ RNA methyltransferase homolog 3 (E. coli) |
| Synonyms | D11Ertd400e, EPCS3, FtsJ RNA 2'-O-methyltransferase 3, SPB1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ftsj3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- O-methyltransferase
- RNA methyltransferase
- viral Cap-0 specific (nucleoside-2'-O-)-methyltransferase
- Spb1 C-terminal domain
- enzyme
- protein binding
- AdoMet_MTases
- Domain of unknown function (DUF3381)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromosome
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ftsj3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
- RNA methylation
- rRNA methylation
- maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Cellular Component
Where in the cell the gene product is active
- chromosome
- nucleolus
- preribosome, small subunit precursor
- nucleoplasm
- preribosome, large subunit precursor
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- rRNA (uridine-2'-O-)-methyltransferase activity
- rRNA (guanine) methyltransferase activity