Lcorl Gene Summary [Mouse]
Predicted to enable histone methyltransferase binding activity. Acts upstream of or within regulation of transcription by RNA polymerase II and transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; early conceptus; oocyte; retina; and trunk somite. Orthologous to human LCORL (ligand dependent nuclear receptor corepressor like). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lcorl |
| Official Name | ligand dependent nuclear receptor corepressor-like [Source:MGI Symbol;Acc:MGI:2651932] |
| Ensembl ID | ENSMUSG00000015882 |
| Bio databases IDs | |
| Aliases | ligand dependent nuclear receptor corepressor-like |
| Synonyms | Gm3414, ligand dependent nuclear receptor corepressor-like, LOC100503788, LOC100912366, MLR1, RGD1561241 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lcorl often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain of unknown function (DUF4553)
- transcription regulator
- enzyme binding
- helix-turn-helix, Psq domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- cardiovascular disorder
- metabolic syndrome X
- hypertension
- insomnia
- lung squamous cell carcinoma
- squamous cell lung cancer
- pervasive developmental disorder
- Parkinson disease
- gastroesophageal reflux
regulates
- DNA promoter
- DNA endogenous promoter
- RNA polymerase II
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lcorl gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding