LCORL Gene Summary [Human]
This gene encodes a transcription factor that appears to function in spermatogenesis. Polymorphisms in this gene are associated with measures of skeletal frame size and adult height. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | LCORL |
| Official Name | ligand dependent nuclear receptor corepressor like [Source:HGNC Symbol;Acc:HGNC:30776] |
| Ensembl ID | ENSG00000178177 |
| Bio databases IDs | |
| Aliases | ligand dependent nuclear receptor corepressor like |
| Synonyms | Gm3414, ligand dependent nuclear receptor corepressor-like, LOC100503788, LOC100912366, MLR1, RGD1561241 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LCORL often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain of unknown function (DUF4553)
- transcription regulator
- enzyme binding
- helix-turn-helix, Psq domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- cardiovascular disorder
- metabolic syndrome X
- hypertension
- insomnia
- lung squamous cell carcinoma
- squamous cell lung cancer
- pervasive developmental disorder
- Parkinson disease
- gastroesophageal reflux
regulates
- DNA promoter
- DNA endogenous promoter
- RNA polymerase II
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LCORL gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding