Ctbp1 Gene Summary [Mouse]
Enables RNA polymerase II-specific DNA-binding transcription factor binding activity; chromatin binding activity; and lncRNA binding activity. Involved in negative regulation of DNA-templated transcription; synaptic vesicle cycle; and white fat cell differentiation. Acts upstream of or within Notch signaling pathway and negative regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription repressor complex. Is active in GABA-ergic synapse; glutamatergic synapse; and presynaptic active zone cytoplasmic component. Is expressed in several structures, including central nervous system; chorionic plate; genitourinary system; limb; and lung. Orthologous to human CTBP1 (C-terminal binding protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ctbp1 |
| Official Name | C-terminal binding protein 1 [Source:MGI Symbol;Acc:MGI:1201685] |
| Ensembl ID | ENSMUSG00000037373 |
| Bio databases IDs | |
| Aliases | C-terminal binding protein 1 |
| Synonyms | 50-kDaBFA-inducedADP-ribosylatedsubstrate, BARS, BARS-50, CTBP, CtBP3/BARS, C-terminal binding protein 1, D4S115h, D5H4S115, D5H4S115E, HADDTS |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ctbp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- transcription co-repressor
- transcription factor binding
- chromatin binding
- protein domain specific binding
- enzyme
- D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
- protein binding
- identical protein binding
- transferase, transferring acyl groups
- PDZ-domain binding
- RNA binding
- NAD or NADH binding
- CH-OH group:NAD or NADP oxidoreductase
- protein homodimerization
- PXDLS-binding domain
- NADH binding domain
- D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
Pathways
Biological processes and signaling networks where the Ctbp1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- head and neck squamous cell carcinoma
- hyperplasia
- non-insulin-dependent diabetes mellitus
- hereditary disorder
- idiopathic scoliosis
- hypotonia, ataxia, developmental delay, and tooth enamel defect syndrome
- head and neck squamous cell cancer
- bleeding
- Waldenström macroglobulinemia
- mental retardation
role in cell
- apoptosis
- production in
- expression in
- growth
- transcription in
- proliferation
- differentiation
- phosphorylation in
- migration
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- polycomb group domain
- glutaminergic synapse
- Cytoplasm
- presynaptic regions
- cell cortex
- Plasma Membrane
- cytosol
- nucleoplasm
- nuclear bodies
- synapse
- ribbon synapse
- synaptosomal fractions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ctbp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- white fat cell differentiation
- negative regulation of transcription, DNA-dependent
- synaptic vesicle endocytosis
- positive regulation of transcription, DNA-dependent
- negative regulation of cell proliferation
- synaptic vesicle clustering
- viral genome replication
- regulation of cell cycle
- protein phosphorylation
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcriptional repressor complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- transcription corepressor binding
- transcription cofactor binding
- identical protein binding
- protein domain specific binding
- protein binding
- oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
- transcription coactivator activity
- NAD binding
- transcription corepressor activity
- chromatin binding