Actr8 Gene Summary [Mouse]
Predicted to enable ATP binding activity. Involved in positive regulation of DNA metabolic process; regulation of embryonic development; and telomere maintenance. Predicted to be located in centrosome and nucleoplasm. Predicted to be part of Ino80 complex. Is expressed in several structures, including early conceptus; liver; metanephros; and oocyte. Orthologous to human ACTR8 (actin related protein 8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Actr8 |
| Official Name | ARP8 actin-related protein 8 [Source:MGI Symbol;Acc:MGI:1860775] |
| Ensembl ID | ENSMUSG00000015971 |
| Bio databases IDs | |
| Aliases | ARP8 actin-related protein 8 |
| Synonyms | 5730542K05Rik, actin related protein 8, Actr8 predicted, ARP8, ARP8 actin-related protein 8, hArp8, INO80N |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Actr8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Actin
- protein binding
- ASKHA_ATPase-like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- centrosome
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Actr8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of DNA repair
- regulation of chromosome organization
- regulation of DNA strand elongation
- regulation of DNA repair
- DNA recombination
- regulation of embryonic development
- telomere maintenance
- regulation of transcription, DNA-dependent
- regulation of DNA replication
- double-strand break repair
- cell division
- chromatin remodeling
- positive regulation of transcription, DNA-dependent
- regulation of cell cycle
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- Ino80 complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding