Actr5 Gene Summary [Mouse]
Involved in positive regulation of DNA metabolic process; regulation of embryonic development; and telomere maintenance. Predicted to be located in nucleus. Predicted to be part of Ino80 complex. Predicted to be active in cytoplasm. Is expressed in bone; brain; cartilage; and genitourinary system. Orthologous to human ACTR5 (actin related protein 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Actr5 |
| Official Name | ARP5 actin-related protein 5 [Source:MGI Symbol;Acc:MGI:1924748] |
| Ensembl ID | ENSMUSG00000037761 |
| Bio databases IDs | |
| Aliases | ARP5 actin-related protein 5 |
| Synonyms | actin related protein 5, Arp5, ARP5 actin-related protein 5, B430109J19RIK, FLJ12785, INO80M |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Actr5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Actin
- protein binding
- ASKHA_ATPase-like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Actr5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of DNA repair
- UV-damage excision repair
- regulation of DNA strand elongation
- regulation of chromosome organization
- regulation of DNA repair
- regulation of embryonic development
- DNA recombination
- telomere maintenance
- regulation of transcription, DNA-dependent
- regulation of DNA replication
- double-strand break repair
- chromatin remodeling
- positive regulation of transcription, DNA-dependent
- regulation of cell cycle
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- Ino80 complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding