Taf6 Gene Summary [Mouse]
Enables DNA binding activity. Predicted to be involved in several processes, including positive regulation of intrinsic apoptotic signaling pathway; positive regulation of transcription initiation by RNA polymerase II; and transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; gut gland; and retina. Orthologous to human TAF6 (TATA-box binding protein associated factor 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Taf6 |
| Official Name | TATA-box binding protein associated factor 6 [Source:MGI Symbol;Acc:MGI:109129] |
| Ensembl ID | ENSMUSG00000036980 |
| Bio databases IDs | |
| Aliases | TATA-box binding protein associated factor 6 |
| Synonyms | ALYUS, MGC:8964, p80, TAF2E, TAF70, TAF(II)70, TAFII-70, TAF(II)80, TAFII-80, TAFII85, TATA-box binding protein associated factor 6, Tata box binding protein-associated factor, tfiid subunit |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Taf6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone-fold domain
- histone fold domain (HFD) superfamily
- transcription regulator
- aryl hydrocarbon receptor binding
- TATA box binding protein associated factor (TAF)
- C-terminal domain of TATA Binding Protein (TBP) Associated Factor 6 (TAF6)
- protein binding
- general RNA polymerase II transcription factor
- TATA box binding protein associated factor
- DNA binding
Pathways
Biological processes and signaling networks where the Taf6 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hereditary disorder
- syndromic mental retardation
- breast cancer
- Alazami-Yuan syndrome
- Cornelia de Lange syndrome type 1
role in cell
- expression in
- apoptosis
- proliferation
- activation in
- growth
- cell cycle progression
- JQ1-sensitivity
- mitosis
- G2 phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Taf6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mRNA transcription from RNA polymerase II promoter
- RNA polymerase II transcriptional preinitiation complex assembly
- positive regulation of transcription initiation from RNA polymerase II promoter
- positive regulation of transcription, DNA-dependent
- regulation of DNA repair
- apoptotic process
- negative regulation of cell cycle
- transcription from RNA polymerase II promoter
- transcription initiation, DNA-dependent
- transcription initiation from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor TFIID complex
- SLIK (SAGA-like) complex
- transcription factor TFTC complex
- cytosol
- macromolecular complex
- SAGA complex
- MLL1 complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- transcription coactivator activity
- protein heterodimerization activity
- aryl hydrocarbon receptor binding
- general RNA polymerase II transcription factor activity