Tfpt Gene Summary [Mouse]
Predicted to enable DNA binding activity and protein kinase binding activity. Involved in positive regulation of DNA metabolic process; regulation of embryonic development; and telomere maintenance. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of Ino80 complex. Predicted to colocalize with actin filament. Orthologous to human TFPT (TCF3 fusion partner). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tfpt |
| Official Name | TCF3 (E2A) fusion partner [Source:MGI Symbol;Acc:MGI:1916964] |
| Ensembl ID | ENSMUSG00000006335 |
| Bio databases IDs | |
| Aliases | TCF3 (E2A) fusion partner |
| Synonyms | 2400004F01Rik, AI450389, Amida, FB1, INO80F, TCF3 (E2A) fusion partner, TCF3 fusion partner |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tfpt often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- protein kinase binding
- nuclear localization sequence
- protein binding
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- actin filaments
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tfpt gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of DNA repair
- DNA repair
- male gonad development
- regulation of chromosome organization
- regulation of DNA strand elongation
- regulation of DNA repair
- DNA recombination
- regulation of embryonic development
- telomere maintenance
- apoptotic signaling pathway
- regulation of DNA replication
- chromatin remodeling
- positive regulation of transcription, DNA-dependent
- positive regulation of apoptotic process
- regulation of cell cycle
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- Ino80 complex
- actin filament
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- DNA binding
- protein binding