Plxdc1 Gene Summary [Mouse]
Predicted to be involved in spinal cord development. Located in cytoplasm and plasma membrane. Orthologous to human PLXDC1 (plexin domain containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Plxdc1 |
| Official Name | plexin domain containing 1 [Source:MGI Symbol;Acc:MGI:1919574] |
| Ensembl ID | ENSMUSG00000017417 |
| Bio databases IDs | |
| Aliases | plexin domain containing 1 |
| Synonyms | 2410003I07Rik, Arl12, Pldc1, plexin domain containing 1, TEM3, TEM7, TUMOR ENDOTHELIAL MARKER 7, tumour ENDOTHELIAL MARKER 7 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Plxdc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Multi-glycosylated core protein 24 (MGC-24), sialomucin
- Plexin repeat
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- osteosarcoma
- squamous-cell carcinoma
- osteosarcomagenesis
- hemangioma
- angiomatosis
- self-abusive behavior
- squamous cell cancer
role in cell
- tubulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- Extracellular Space
- cellular membrane
- tight junctions
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Plxdc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- angiogenesis
- spinal cord development
Cellular Component
Where in the cell the gene product is active
- dendrite
- tight junction
- cytoplasm
- receptor complex
- neuronal cell body
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding