Nkiras2 Gene Summary [Mouse]
Enables GTPase activating protein binding activity. Acts upstream of or within several processes, including Ral protein signal transduction; regulation of signal transduction; and surfactant homeostasis. Predicted to be located in cytoplasm. Is expressed in cerebral cortex; dorsal root ganglion; and nose. Orthologous to human NKIRAS2 (NFKB inhibitor interacting Ras like 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nkiras2 |
| Official Name | NFKB inhibitor interacting Ras-like protein 2 [Source:MGI Symbol;Acc:MGI:1919216] |
| Ensembl ID | ENSMUSG00000017837 |
| Bio databases IDs | |
| Aliases | NFKB inhibitor interacting Ras-like protein 2 |
| Synonyms | 2410003M04Rik, 4930527H08Rik, D630018G21Rik, kappaB-Ras2, KBRAS2, NFKB inhibitor interacting Ras-like 2, NFKB inhibitor interacting Ras-like protein 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nkiras2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- small GTP-binding protein domain
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- Rab subfamily of small GTPases
- enzyme
- protein binding
- Ras of Complex, Roc, domain of DAPkinase
- P-loop containing Nucleoside Triphosphate Hydrolases
- Ras subfamily of RAS small GTPases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nkiras2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lung alveolus development
- inflammatory response
- Ral protein signal transduction
- regulation of tumor necrosis factor-mediated signaling pathway
- negative regulation of I-kappaB kinase/NF-kappaB cascade
- surfactant homeostasis
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- GTP binding
- GTPase activity
- GTPase activating protein binding