Tubb1 Gene Summary [Mouse]
A structural constituent of cytoskeleton. Involved in several processes, including platelet aggregation; platelet formation; and thyroid hormone transport. Acts upstream of or within spindle assembly. Located in microtubule. Is expressed in dorsal root ganglion; liver; and spinal cord. Human ortholog(s) of this gene implicated in autosomal dominant isolated macrothrombocytopenia 1. Orthologous to human TUBB1 (tubulin beta 1 class VI). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tubb1 |
| Official Name | tubulin, beta 1 class VI [Source:MGI Symbol;Acc:MGI:107814] |
| Ensembl ID | ENSMUSG00000016255 |
| Bio databases IDs | |
| Aliases | tubulin, beta 1 class VI |
| Synonyms | 2810484G07RIK, Beta1 tubulin, MACTHC1, M(beta)1, M(β)1, tubulin beta 1 class VI, tubulin, beta 1 class VI, tubulin β 1 class VI, tubulin, β 1 class VI, β-tubulin class I |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tubb1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Tubulin protein family of FtsZ and CetZ-like
- Tubulin C-terminal domain
- structural constituent of cytoskeleton
- Tubulin/FtsZ family, GTPase domain
- Tubulin/FtsZ family, C-terminal domain
Pathways
Biological processes and signaling networks where the Tubb1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- human immunodeficiency virus I infection
- HIV infection
- infection
- chronic infection
- disorder of coronary artery
- mantle cell lymphoma
- diffuse large B-cell lymphoma
- CD20-negative monomorphic T cell post-transplant lymphoma
- pancreatic cancer
- metastatic pancreatic adenocarcinoma
role in cell
- formation
- quantity
- function
- assembly
- shape
- breakage
- production
- thickness
- deformation
- aggregation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule cytoskeleton
- microtubules
- cytoplasmic bridges
- nucleoli
- membrane rafts
- mitotic spindle
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tubb1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spindle assembly
- thyroid gland development
- platelet formation
- microtubule polymerization
- microtubule cytoskeleton organization
- platelet aggregation
- mitotic cell cycle
- thyroid hormone transport
Cellular Component
Where in the cell the gene product is active
- intercellular bridge
- microtubule cytoskeleton
- extracellular vesicular exosome
- mitotic spindle
- cytoplasm
- microtubule
Molecular Function
What the gene product does at the molecular level
- GTP binding
- metal ion binding
- GTPase activity
- structural constituent of cytoskeleton