Ralgapa1 Gene Summary [Mouse]
Predicted to enable GTPase activator activity and protein heterodimerization activity. Acts upstream of with a negative effect on negative regulation of DNA-binding transcription factor activity. Located in cytoplasm and nucleus. Is expressed in several structures, including 1st branchial arch; brain; metanephros; placenta; and trunk. Orthologous to human RALGAPA1 (Ral GTPase activating protein catalytic subunit alpha 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ralgapa1 |
| Official Name | Ral GTPase activating protein, alpha subunit 1 [Source:MGI Symbol;Acc:MGI:1931050] |
| Ensembl ID | ENSMUSG00000021027 |
| Bio databases IDs | |
| Aliases | Ral GTPase activating protein, alpha subunit 1 |
| Synonyms | 2310003F20Rik, 4930400K19Rik, GARNL1, GARNL2, GRIPE, mKIAA0884, NEDHRIT, RalGAPalpha1, Ral GTPase activating protein, alpha subunit 1, Ral GTPase activating protein catalytic subunit alpha 1, Ral GTPase activating protein catalytic subunit α 1, Ral GTPase activating protein, α subunit 1, TULIP1, Tulip2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ralgapa1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rap/ran-GAP
- GTPase activator
- protein binding
- protein heterodimerization
- RALGAPB N-terminal domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- neurodevelopmental disorder with hypotonia, neonatal respiratory insufficiency, and thermodysregulation
- fibrosis
- hereditary disorder
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ralgapa1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of small GTPase mediated signal transduction
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein heterodimerization activity
- GTPase activator activity