B4galt5 Gene Summary [Mouse]
Enables N-acetyllactosamine synthase activity and UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity. Involved in several processes, including ganglioside biosynthetic process via lactosylceramide; neurogenesis; and positive regulation of embryonic development. Acts upstream of or within poly-N-acetyllactosamine biosynthetic process. Predicted to be located in Golgi cisterna membrane. Predicted to be active in Golgi apparatus. Is expressed in several structures, including epithelium; genitourinary system; heart; nervous system; and respiratory system. Orthologous to human B4GALT5 (beta-1,4-galactosyltransferase 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | B4galt5 |
| Official Name | UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 5 [Source:MGI Symbol;Acc:MGI:1927169] |
| Ensembl ID | ENSMUSG00000017929 |
| Bio databases IDs | |
| Aliases | UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 5 |
| Synonyms | 9430078I07Rik, beta-1,4-galactosyltransferase 5, beta-1,4 GalTV, beta4Gal-T5, BETA4-GALT-IV, beta4GalT-V, gt-V, UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase polypeptide 5, UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 5, UDP-Gal:betaGlcNAc β 1,4-galactosyltransferase polypeptide 5, UDP-Gal:betaGlcNAc β 1,4-galactosyltransferase, polypeptide 5, β-1,4-galactosyltransferase 5, β-1,4 GalTV |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse B4galt5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase
- UDP-galactose-glucosylceramide beta-1,4-galactosyltransferase
- galactosyltransferase
- N-terminal domain of galactosyltransferase
- N-terminal region of glycosyl transferase group 7
- enzyme
- protein binding
- N-acetyllactosamine synthase
- glycosyltransferase family A
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- Huntington disease
- lung cancer
- systemic sclerosis
- Marfan syndrome
- alloxan-induced diabetic nephropathy
- glioma
- glioma formation
regulates
- AKT
- NOTCH1
- Shiga toxin 2
- poly-N-acetyllactosamine
- O-glycan
- N-glycan
role in cell
- apoptosis
- expression in
- survival
- tubulation
- invasion
- galactosylation in
- maturation
- axonogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi Apparatus
- Golgi membrane
- trans Golgi cisternae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse B4galt5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glycoprotein biosynthetic process
- central nervous system neuron axonogenesis
- protein glycosylation
- neuron maturation
- positive regulation of embryonic development
- glycosylation
- ganglioside biosynthetic process via lactosylceramide
- central nervous system myelination
- carbohydrate metabolic process
- regulation of protein stability
- O-glycan processing
- poly-N-acetyllactosamine biosynthetic process
Cellular Component
Where in the cell the gene product is active
- Golgi cisterna membrane
- Golgi apparatus
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- N-acetyllactosamine synthase activity
- metal ion binding
- UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity
- galactosyltransferase activity