Syt12 Gene Summary [Mouse]
Predicted to enable SNARE binding activity; calcium ion sensor activity; and calcium-dependent phospholipid binding activity. Involved in long-term synaptic potentiation and presynaptic modulation of chemical synaptic transmission. Is active in hippocampal mossy fiber to CA3 synapse and synaptic vesicle membrane. Colocalizes with synaptic vesicle. Is expressed in adrenal gland and ventral grey horn. Orthologous to human SYT12 (synaptotagmin 12). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Syt12 |
| Official Name | synaptotagmin XII [Source:MGI Symbol;Acc:MGI:2159601] |
| Ensembl ID | ENSMUSG00000049303 |
| Bio databases IDs | |
| Aliases | synaptotagmin XII |
| Synonyms | Srg1, synaptotagmin 12, synaptotagmin XII, SYT11, sytXII |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Syt12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Protein kinase C conserved region 2 (CalB)
- transporter
- C2 domain
Pathways
Biological processes and signaling networks where the Syt12 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung adenocarcinoma
- lung adenocarcinoma formation
- diabetic nephropathy
- papillary thyroid carcinoma
- papillary thyroid cancer
- schizophrenia
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- synaptic vesicle membrane
- presynaptic regions
- synaptic membrane
- synaptic vesicles
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Syt12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- calcium ion-independent exocytosis of neurotransmitter
- calcium ion-dependent exocytosis
- long-term synaptic potentiation
Cellular Component
Where in the cell the gene product is active
- exocytic vesicle
- synaptic vesicle membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylserine binding
- calcium ion binding
- clathrin binding
- SNARE binding
- calcium-dependent phospholipid binding