Ets1 Gene Summary [Mouse]
Enables DNA-binding transcription factor activity; DNA-binding transcription factor binding activity; and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of inflammatory response and positive regulation of transcription by RNA polymerase II. Acts upstream of or within regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human ETS1 (ETS proto-oncogene 1, transcription factor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Ets1 |
| Official Name | E26 avian leukemia oncogene 1, 5' domain [Source:MGI Symbol;Acc:MGI:95455] |
| Ensembl ID | ENSMUSG00000032035 |
| Bio databases IDs | |
| Aliases | E26 avian leukemia oncogene 1, 5' domain |
| Synonyms | AI196000, c-ets-1, D230050P06, E26 avian leukaemia oncogene 1, 5' domain, E26 avian leukemia oncogene 1, 5' domain, Etsoncb, ETS proto-oncogene 1, transcription factor, EWSR2, p42 ETS1, p54, TPL1, v-Ets, vs |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ets1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- activation domain
- transcription regulator
- transcription co-activator
- transcription factor binding domain
- DNA binding domain
- nucleic acid binding
- SAM (Sterile alpha motif )
- transcription activation domain
- transcription factor binding
- protein binding
- sequence-specific DNA binding
- identical protein binding
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- Sterile alpha motif (SAM)/Pointed domain
- double-stranded DNA binding
- Ets-domain
- pointed domain
- Ets1 N-terminal flanking region of Ets domain
- transcription factor activity
- histone acetyltransferase binding
- self-inhibitory domain
Pathways
Biological processes and signaling networks where the Ets1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- neoplasia
- acute myeloid leukemia
- COVID-19
- prostate cancer
- non-Hodgkin disease
- glaucoma
- epithelial cancer
- non-Hodgkin lymphoma
- non-insulin-dependent diabetes mellitus
role in cell
- activation in
- formation
- expression in
- cell death
- apoptosis
- cellular infiltration by
- binding in
- migration
- morphology
- size
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- nucleoplasm
- chromatin
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ets1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cell proliferation
- positive regulation of inflammatory response
- regulation of angiogenesis
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of erythrocyte differentiation
- positive regulation of angiogenesis
- positive regulation of blood vessel endothelial cell migration
- regulation of transcription from RNA polymerase II promoter
- cell motility
- immune response
- positive regulation of transcription, DNA-dependent
- positive regulation of gene expression
- cell differentiation
- positive regulation of endothelial cell migration
- PML body organization
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- transcription corepressor binding
- nucleic acid binding
- DNA binding
- sequence-specific DNA binding transcription factor activity
- identical protein binding
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- ligand-dependent nuclear receptor transcription coactivator activity
- transcription regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity