Rplp2 Gene Summary [Mouse]
Predicted to enable iron ion binding activity and ribonucleoprotein complex binding activity. Predicted to be involved in cytoplasmic translation; translation at postsynapse; and translation at presynapse. Located in cytoplasm. Part of cytosolic large ribosomal subunit. Is active in synapse. Is expressed in several structures, including central nervous system and retina. Orthologous to human RPLP2 (ribosomal protein lateral stalk subunit P2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rplp2 |
| Official Name | ribosomal protein, large P2 [Source:MGI Symbol;Acc:MGI:1914436] |
| Ensembl ID | ENSMUSG00000025508 |
| Bio databases IDs | |
| Aliases | ribosomal protein, large P2 |
| Synonyms | 2700049I22Rik, D11S2243E, LOC100911575, LP2, P2, ribosomal protein lateral stalk subunit P2, Ribosomal Protein P2 Acidic, RP2, RPP2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rplp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 60s Acidic ribosomal protein
- structural constituent of ribosome
- ribonucleoprotein binding
- iron ion binding
- protein binding
Pathways
Biological processes and signaling networks where the Rplp2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- neoplasia
- organismal death
- systemic autoimmune syndrome
- hepatocellular carcinoma
- liver cancer
- Fuchs endothelial dystrophy
- Alzheimer disease
- aortic valve calcification
role in cell
- expression in
- ferroptosis
- proliferation
- migration
- colony formation
- translation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- ribosome
- Plasma Membrane
- cytosol
- endoplasmic reticulum membrane
- synapse
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rplp2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytoplasmic translation
- cytoplasmic translational elongation
- translation
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- focal adhesion
- cytoplasm
- membrane
- cytosol
- cytosolic large ribosomal subunit
Molecular Function
What the gene product does at the molecular level
- protein binding
- structural constituent of ribosome