Mief2 Gene Summary [Mouse]
Involved in positive regulation of mitochondrial fission. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial outer membrane. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 49. Orthologous to human MIEF2 (mitochondrial elongation factor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mief2 |
| Official Name | mitochondrial elongation factor 2 [Source:MGI Symbol;Acc:MGI:2144199] |
| Ensembl ID | ENSMUSG00000018599 |
| Bio databases IDs | |
| Aliases | mitochondrial elongation factor 2 |
| Synonyms | AI482195, COXPD49, D3B, Gm11, MID49, mitochondrial elongation factor 2, RGD1560728, SMCR7 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mief2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- ovarian cancer
- combined oxidative phosphorylation deficiency 49
role in cell
- colony formation
- production in
- expression in
- apoptosis
- proliferation
- phosphorylation in
- cell viability
- migration
- width
- G1 phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial outer membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mief2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein targeting to membrane
- mitochondrial fusion
- regulation of mitochondrion organization
- positive regulation of mitochondrial fission
- mitochondrion organization
Cellular Component
Where in the cell the gene product is active
- peroxisome
- mitochondrion
- mitochondrial outer membrane
Molecular Function
What the gene product does at the molecular level
- protein binding