H13 Gene Summary [Mouse]
Predicted to enable aspartic endopeptidase activity, intramembrane cleaving; protein homodimerization activity; and ubiquitin protein ligase binding activity. Acts upstream of or within in utero embryonic development. Located in cell surface and endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; brain; embryo ectoderm; extraembryonic component; and musculoskeletal system. Orthologous to human HM13 (histocompatibility minor 13). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | H13 |
| Official Name | histocompatibility 13 [Source:MGI Symbol;Acc:MGI:95886] |
| Ensembl ID | ENSMUSG00000019188 |
| Bio databases IDs | |
| Aliases | histocompatibility 13 |
| Synonyms | 1200006O09Rik, 4930443L17Rik, 5031424B04Rik, H13, histocompatibility 13, histocompatibility minor 13, IMP1, IMPAS, IMPAS-1, MSTP086, PSENL3, PSL3, SPP, SPPL1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse H13 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- aspartic endopeptidase, intramembrane cleaving
- ubiquitin protein ligase binding
- peptidase
- protein homodimerization
- protein binding
- Signal peptide peptidase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic obstructive pulmonary disease
phenotypes
- abnormal snout morphology
- decreased fasting circulating glucose level
- decreased total body fat amount
- increased bone mineral content
- preweaning lethality complete penetrance
- abnormal Mullerian duct morphology
- abnormal Wolffian duct morphology
- abnormal azygos vein topology
- abnormal brachial plexus formation
- abnormal brain internal capsule morphology
- abnormal brain morphology
- abnormal cervical atlas morphology
- abnormal chorion morphology
- abnormal ductus venosus valve morphology
- abnormal eye muscle morphology
- abnormal forebrain development
- abnormal forebrain morphology
- abnormal hepatic vein morphology
- abnormal hindbrain morphology
- abnormal hypoglossal canal morphology
- abnormal hypoglossal nerve topology
- abnormal inferior vena cava valve morphology
- abnormal infrahyoid muscle connection
- abnormal infrahyoid muscle morphology
- abnormal interatrial septum morphology
- abnormal intestine placement
- abnormal liver vasculature morphology
- abnormal nervous system morphology
- abnormal olfactory bulb morphology
- abnormal optic chiasm morphology
- abnormal optic cup morphology
- abnormal optic stalk morphology
- abnormal outer ear morphology
- abnormal pancreas topology
- abnormal placenta morphology
- abnormal placental labyrinth vasculature morphology
- abnormal posterior semicircular canal morphology
- abnormal pulmonary valve cusp morphology
- abnormal rib morphology
- abnormal stapedial artery morphology
- abnormal stapedial artery topology
- abnormal styloid process morphology
- abnormal tail morphology
- abnormal thymus topology
- abnormal trophoblast giant cell morphology
- abnormal trophoblast layer morphology
- abnormal umbilical vein topology
- abnormal vertebrae morphology
- abnormal vertebral arch morphology
- abnormal vertebral artery origin
- abnormal vitelline vein connection
- abnormal vitelline vein topology
- absent Mullerian ducts
- absent celiac artery
- absent ductus venosus valve
- absent hypoglossal canal
- absent hypoglossal nerve
- absent inferior vena cava
- absent kidney
- absent posterior communicating artery
- absent ribs
- absent segment of posterior cerebral artery
- absent stapedial artery
- absent superior cervical ganglion
- blood in lymph vessels
- decreased length of long bones
- double outlet right ventricle
- embryo tumor
- enlarged liver sinusoidal spaces
- enlarged paraumbilical vein
- exencephaly
- fused dorsal root ganglion
- heterochrony
- left pulmonary isomerism
- multiple persisting craniopharyngeal ducts
- muscular ventricular septal defect
- perimembraneous ventricular septal defect
- persistent dorsal ophthalmic artery
- reduced sympathetic cervical ganglion size
- retroesophageal right subclavian artery
- situs inversus
- small kidney
- small placenta
- small superior cervical ganglion
- small thyroid gland
- subcutaneous edema
- symmetric azygos veins
- thin hypoglossal nerve
- thoracoschisis
- transposition of great arteries
role in cell
- production in
- molecular cleavage in
- response by
- senescence
- endoplasmic reticulum-associated degradation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- cell surface
- cellular membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- rough endoplasmatic reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse H13 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- membrane protein ectodomain proteolysis
- in utero embryonic development
- membrane protein intracellular domain proteolysis
- membrane protein proteolysis
- cellular response to oxidative stress
- signal peptide processing
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- rough endoplasmic reticulum
- endoplasmic reticulum
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- ubiquitin protein ligase binding
- protein homodimerization activity
- protein binding
- peptidase activity
- aspartic endopeptidase activity, intramembrane cleaving