Noxo1 Gene Summary [Mouse]
Enables superoxide-generating NADPH oxidase activator activity. Acts upstream of or within superoxide metabolic process. Located in plasma membrane. Is expressed in inner ear vestibular component; rectum; and submandibular gland primordium. Orthologous to human NOXO1 (NADPH oxidase organizer 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Noxo1 |
| Official Name | NADPH oxidase organizer 1 [Source:MGI Symbol;Acc:MGI:1919143] |
| Ensembl ID | ENSMUSG00000019320 |
| Bio databases IDs | |
| Aliases | NADPH oxidase organizer 1 |
| Synonyms | 2310034C04Rik, hslt, NADPH oxidase organizer 1, P41NOX, P41NOXA, P41NOXB, P41NOXC, SH3PXD5, SNX28 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Noxo1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipid binding
- superoxide-generating NADPH oxidase activator
- enzyme binding
- The Phox Homology domain, a phosphoinositide binding module
- protein binding
- PX domain
- Src Homology 3 domain superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- gastritis
- gastrointestinal neoplasia
- colon cancer
- dry eye syndrome
- stomach neoplasm
role in cell
- expression in
- production in
- activation in
- generation in
- growth
- disassembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Nucleus
- granules
- cytoplasmic aggregates
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Noxo1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- extracellular matrix disassembly
- regulation of respiratory burst
- superoxide anion generation
- regulation of hydrogen peroxide metabolic process
Cellular Component
Where in the cell the gene product is active
- NADPH oxidase complex
- cytoplasm
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- phosphatidylinositol binding
- superoxide-generating NADPH oxidase activator activity
- phospholipid binding
- enzyme binding