Pask Gene Summary [Mouse]
Predicted to enable phosphatidylinositol binding activity and protein serine/threonine kinase activity. Involved in energy homeostasis; regulation of glucagon secretion; and regulation of respiratory gaseous exchange. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including brain ventricular layer; colon; liver; placenta; and spleen. Orthologous to human PASK (PAS domain containing serine/threonine kinase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Pask |
| Official Name | PAS domain containing serine/threonine kinase [Source:MGI Symbol;Acc:MGI:2155936] |
| Ensembl ID | ENSMUSG00000026274 |
| Bio databases IDs | |
| Aliases | PAS domain containing serine/threonine kinase |
| Synonyms | DKFZp434O051, mKIAA0135, PAS domain containing serine/threonine kinase, PASKIN, STK37 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pask often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- Protein tyrosine and serine/threonine kinase
- PAS
- protein binding
- Protein kinase domain
- PAS fold
- phosphatidylinositol binding
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Protein Kinases, catalytic domain
- PAS domain
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- lung squamous cell carcinoma
- squamous cell lung cancer
- plasma cell myeloma
- insulin resistance
role in cell
- phosphorylation in
- degradation in
- expression in
- serine phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoskeleton
- intracellular space
- cellular tail
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pask gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of translation
- negative regulation of glycogen biosynthetic process
- energy homeostasis
- protein autophosphorylation
- regulation of respiratory gaseous exchange
- protein phosphorylation
- regulation of glucagon secretion
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- phosphatidylinositol binding
- protein serine/threonine kinase activity