Noxa1 Gene Summary [Mouse]
Enables superoxide-generating NADPH oxidase activator activity. Acts upstream of or within superoxide metabolic process. Predicted to be located in cytoplasm. Predicted to be part of NADPH oxidase complex. Is expressed in pancreas and pancreas tip epithelium. Orthologous to human NOXA1 (NADPH oxidase activator 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Noxa1 |
| Official Name | NADPH oxidase activator 1 [Source:MGI Symbol;Acc:MGI:2449980] |
| Ensembl ID | ENSMUSG00000036805 |
| Bio databases IDs | |
| Aliases | NADPH oxidase activator 1 |
| Synonyms | NADPH oxidase activator 1, NY-CO-31, p51NOX, SDCCAG31 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Noxa1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- activation domain
- superoxide-generating NADPH oxidase activator
- enzyme binding
- protein binding
- identical protein binding
- tetratricopeptide repeat
- PB1
- SH3-domain binding
- phosphorylation site
- Src Homology 3 domain superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- adult T-cell leukemia/lymphoma
- mature T-cell neoplasia
- T-cell non-Hodgkin disease
role in cell
- migration
- production in
- activation in
- formation in
- binding in
- generation in
- glycolysis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membranes
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Noxa1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- superoxide metabolic process
- regulation of respiratory burst
- regulation of hydrogen peroxide metabolic process
- superoxide anion generation
Cellular Component
Where in the cell the gene product is active
- NADPH oxidase complex
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- small GTPase binding
- superoxide-generating NADPH oxidase activator activity
- SH3 domain binding
- enzyme binding