Rgs17 Gene Summary [Mouse]
Predicted to enable GTPase activator activity. Predicted to be involved in negative regulation of signal transduction. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in several cellular components, including neuron projection; nucleus; and synapse. Orthologous to human RGS17 (regulator of G protein signaling 17). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rgs17 |
| Official Name | regulator of G-protein signaling 17 [Source:MGI Symbol;Acc:MGI:1927469] |
| Ensembl ID | ENSMUSG00000019775 |
| Bio databases IDs | |
| Aliases | regulator of G-protein signaling 17 |
| Synonyms | 6430507P11Rik, hRGS17, regulator of G-protein signaling 17, Regulator of G-protein signalling 17, RGSZ2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rgs17 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Regulator of G protein signaling domain
- Regulator of G protein signaling (RGS) domain superfamily
- GTPase
- GTPase activator
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the Rgs17 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- prostatic carcinoma
- metabolic syndrome X
- prostate cancer
- epithelial cancer
- insulin-dependent diabetes mellitus
- organismal death
- small cell lung cancer
- attention deficit hyperactivity disorder
- covid-19 death
regulates
- Ca2+
- cyclic AMP
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rgs17 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of signal transduction
- response to amphetamine
- G-protein coupled receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- synapse
- neuron projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- GTPase activity
- GTPase activator activity