Myoc Gene Summary [Mouse]
Enables receptor tyrosine kinase binding activity. Involved in several processes, including ERBB2-ERBB3 signaling pathway; neurogenesis; and skeletal muscle hypertrophy. Located in several cellular components, including Golgi apparatus; endoplasmic reticulum; and node of Ranvier. Is expressed in several structures, including brain; eye; genitourinary system; lung; and meninges. Used to study open-angle glaucoma. Human ortholog(s) of this gene implicated in juvenile glaucoma; low tension glaucoma; ocular hypertension; open-angle glaucoma; and primary open angle glaucoma. Orthologous to human MYOC (myocilin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Myoc |
| Official Name | myocilin [Source:MGI Symbol;Acc:MGI:1202864] |
| Ensembl ID | ENSMUSG00000026697 |
| Bio databases IDs | |
| Aliases | myocilin |
| Synonyms | GLC1A, GPOA, JOAG, JOAG1, myocilin, TIGR |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Myoc often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- myosin binding
- Apg6 coiled-coil region
- Autophagy protein 16 (ATG16)
- TPR/MLP1/MLP2-like protein
- frizzled binding
- receptor tyrosine kinase binding
- Olfactomedin-like domain
- Coiled-coiled domain of autophagy-related 16 (Atg16) family proteins
- coiled-coil domain
- protein binding
- olfactomedin domain
- fibronectin binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- open angle glaucoma type 1A
- colorectal cancer
- pediatric glaucoma
- aortic valve calcification
- digenic primary congenital glaucoma type 3A
- digenic open angle glaucoma 1A
- primary open-angle glaucoma
- open angle glaucoma type 1E
- open-angle glaucoma
- muscular hypertrophy
role in cell
- adhesion
- proliferation
- apoptosis
- expression in
- migration
- loss
- generation
- cell death
- differentiation
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell surface
- Extracellular Space
- perinuclear region
- Nucleus
- Plasma Membrane
- basal bodies
- vesicles
- Golgi Apparatus
- Endoplasmic Reticulum
- sarcoplasm
- mitochondrial intermembrane space
- mitochondrial outer membrane
- mitochondrial inner membrane
- nodes of Ranvier
- myelin sheath outer loop
- mesaxons
- Schmidt-Lanterman incisures
- sarcolemma
- cytoplasmic vesicles
- extracellular matrix
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Myoc gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of Rho protein signal transduction
- regulation of MAPK cascade
- neuron projection development
- signal transduction
- ERBB2-ERBB3 signaling pathway
- positive regulation of substrate adhesion-dependent cell spreading
- bone development
- clustering of voltage-gated sodium channels
- myelination in peripheral nervous system
- negative regulation of stress fiber assembly
- positive regulation of focal adhesion assembly
- negative regulation of cell-matrix adhesion
- positive regulation of stress fiber assembly
- positive regulation of JNK cascade
- osteoblast differentiation
- positive regulation of mitochondrial depolarization
- skeletal muscle hypertrophy
- positive regulation of protein kinase B signaling cascade
- non-canonical Wnt receptor signaling pathway
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- extracellular space
- mitochondrial intermembrane space
- extracellular vesicular exosome
- cilium
- cytoplasmic vesicle
- node of Ranvier
- rough endoplasmic reticulum
- Golgi apparatus
- endoplasmic reticulum
- mitochondrial outer membrane
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- frizzled binding
- protein binding
- metal ion binding
- fibronectin binding
- receptor tyrosine kinase binding
- myosin light chain binding