Trdn Gene Summary [Mouse]
Predicted to enable protein-macromolecule adaptor activity. Involved in heart contraction. Acts upstream of or within establishment of localization in cell; release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; and response to bacterium. Predicted to be located in cytosol; nucleoplasm; and sarcoplasmic reticulum. Predicted to be part of calcium channel complex and junctional membrane complex. Predicted to be active in junctional sarcoplasmic reticulum membrane and plasma membrane. Is expressed in embryo and heart. Human ortholog(s) of this gene implicated in catecholaminergic polymorphic ventricular tachycardia and catecholaminergic polymorphic ventricular tachycardia 5. Orthologous to human TRDN (triadin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Trdn |
| Official Name | triadin [Source:MGI Symbol;Acc:MGI:1924007] |
| Ensembl ID | ENSMUSG00000019787 |
| Bio databases IDs | |
| Aliases | triadin |
| Synonyms | 2310045H21Rik, CARDAR, CPVT5, EG432451, JUNCTIONAL SARCOPLASMIC RETICULUM GLYCOPROTEIN, TDN, triadin, TRISK |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Trdn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding activity, bridging
- ion channel binding
- protein binding
Pathways
Biological processes and signaling networks where the Trdn gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- catecholaminergic polymorphic ventricular tachycardia type 1
- catecholaminergic polymorphic ventricular tachycardia type 5
- hypertrophic cardiomyopathy
- breast cancer
- endometriosis
- catecholaminergic polymorphic ventricular tachycardia
- neuropathy
- drug allergy
- long-QT syndrome
- cocaine-related disorder
role in cell
- abnormal morphology
- orientation
- homeostasis in
- organization
- volume
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- junctional membrane complex
- cellular membrane
- Plasma Membrane
- sarcoplasmic reticulum
- Endoplasmic Reticulum
- Mitochondria
- triad junctions
- cytosol
- microsome
- nucleoplasm
- Z line
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Trdn gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cardiac muscle cell membrane potential
- regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
- heart contraction
- endoplasmic reticulum membrane organization
- positive regulation of ryanodine-sensitive calcium-release channel activity
- cellular calcium ion homeostasis
- negative regulation of ryanodine-sensitive calcium-release channel activity
- regulation of release of sequestered calcium ion into cytosol
- response to bacterium
- release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
- muscle contraction
- regulation of cell communication by electrical coupling
- cytoplasmic microtubule organization
- establishment of localization in cell
Cellular Component
Where in the cell the gene product is active
- sarcoplasmic reticulum
- membrane
- cytosol
- endoplasmic reticulum
- junctional sarcoplasmic reticulum membrane
- plasma membrane
- junctional membrane complex
- sarcoplasmic reticulum lumen
- sarcoplasmic reticulum membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein binding, bridging
- receptor binding
- ion channel binding