Dnmt3a Gene Summary [Mouse]
This is one of two related genes encoding de novo DNA methyltransferases, which are responsible for the establishment of DNA methylation patterns in embryos. Loss of function of this gene causes developmental defects in multiple different organ systems. There is a pseudogene for this gene located on chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Nov 2012]
Details
| Type | Retained Intron |
| Official Symbol | Dnmt3a |
| Official Name | DNA methyltransferase 3A [Source:MGI Symbol;Acc:MGI:1261827] |
| Ensembl ID | ENSMUSG00000020661 |
| Bio databases IDs | |
| Aliases | DNA methyltransferase 3A |
| Synonyms | DNA Methyltransferase 3A, DNA methyltransferase 3 alpha, DNA methyltransferase 3 α, DNA MTase HsaIIIA, DNMT3A2, HESJAS, M.HsaIIIA, MmuIIIA, TBRS |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dnmt3a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription co-repressor
- PWWP domain
- transcription factor binding
- chromatin binding
- enzyme
- AdoMet_MTases
- DNA (cytosine-5-)-methyltransferase
- S-adenosylmethionine-dependent methyltransferase
- identical protein binding
- methyltransferase domain
- FYVE domain like superfamily
- protein methyltransferase
- ATRX-homology domain
- catalytic domain
- nucleic acid binding
- PWWP (Pro-Trp-Trp-Pro) domain
- protein binding
- sequence-specific DNA binding
- DNA binding
- RNA binding
- Cysteine rich ADD domain in DNMT3
- unmethylated CpG binding
- double-stranded DNA binding
- S-methyltransferase
- DNA-methyltransferase (dcm)
Pathways
Biological processes and signaling networks where the Dnmt3a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- neoplasia
- endometriosis
- cancer
- Tatton-Brown-Rahman syndrome
- breast adenocarcinoma
- serous ovarian adenocarcinoma
- serous ovarian cancer
- cardiovascular disorder
- lung adenocarcinoma
role in cell
- migration
- accumulation
- apoptosis
- expression in
- proliferation
- production in
- signaling in
- phosphorylation in
- cell death
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- chromatin fraction
- nuclear matrix fraction
- heterochromatin
- Cytoplasm
- nuclear foci
- chromosome
- nucleoplasm
- sex chromatin
- nuclear matrix
- centromeres
- chromatin
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dnmt3a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron differentiation
- spermatogenesis
- response to cocaine
- hypermethylation of CpG island
- response to xenobiotic stimulus
- S-adenosylmethionine metabolic process
- response to toxin
- positive regulation of cellular response to hypoxia
- methylation-dependent chromatin silencing
- hepatocyte apoptotic process
- negative regulation of transcription from RNA polymerase II promoter
- cellular response to ethanol
- cellular response to amino acid stimulus
- negative regulation of transcription, DNA-dependent
- response to estradiol stimulus
- response to vitamin A
- cellular response to hypoxia
- response to lead ion
- chromatin silencing by small RNA
- methylation
- response to ionizing radiation
Cellular Component
Where in the cell the gene product is active
- XY body
- heterochromatin
- nucleus
- euchromatin
- cytoplasm
- nuclear matrix
- chromosome, centromeric region
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA (cytosine-5-)-methyltransferase activity
- DNA binding
- identical protein binding
- protein binding
- transcription corepressor activity
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- unmethylated CpG binding
- chromatin binding