Trpc3 Gene Summary [Mouse]
Predicted to enable calcium-activated cation channel activity; inositol 1,4,5 trisphosphate binding activity; and store-operated calcium channel activity. Predicted to be involved in several processes, including positive regulation of calcium ion transport into cytosol; positive regulation of cardiac muscle hypertrophy in response to stress; and response to ATP. Predicted to be part of cation channel complex. Predicted to be active in plasma membrane. Is expressed in several structures, including cochlea; ganglia; gonad; spinal cord; and trunk somite. Human ortholog(s) of this gene implicated in cerebellar ataxia type 41. Orthologous to human TRPC3 (transient receptor potential cation channel subfamily C member 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Trpc3 |
| Official Name | transient receptor potential cation channel, subfamily C, member 3 [Source:MGI Symbol;Acc:MGI:109526] |
| Ensembl ID | ENSMUSG00000027716 |
| Bio databases IDs | |
| Aliases | transient receptor potential cation channel, subfamily C, member 3 |
| Synonyms | Mwk, SCA41, transient receptor potential cation channel subfamily C member 3, transient receptor potential cation channel, subfamily C, member 3, Trcp3, TRP3, TrpC3c, Trrp3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Trpc3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calcium activated cation channel
- Ankyrin repeats (many copies)
- Ion transport protein
- calcium channel
- Ankyrin repeats (3 copies)
- store-operated calcium channel
- protein binding
- Src-homology 2 binding domain
- proline rich domain
- ion channel
- inositol 1,4,5-triphosphate receptor binding domain
- ankyrin binding domain
- binding protein
- Transient receptor ion channel II
- transient-receptor-potential calcium channel protein
- Transient Receptor Potential channel, Vanilloid subfamily (TRPV)
- Polycystin cation channel
Pathways
Biological processes and signaling networks where the Trpc3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- spinocerebellar ataxia type 41
- ataxia
- hyperplasia
- mechanical hypersensitivity
- cardiomyopathy
- allergic asthma
- cardiac hypertrophy
- hypersensitive reaction
- gait disturbance
role in cell
- expression in
- tubulation
- loss
- growth
- proliferation
- formation
- formation in
- influx in
- induction in
- growth in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- dendritic tuft
- cell surface
- cellular membrane
- sarcomere
- apical membrane
- synaptosomes
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Trpc3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to ATP
- response to calcium ion
- calcium ion transport
- cytosolic calcium ion homeostasis
- calcium ion transmembrane transport
- positive regulation of calcium ion transport into cytosol
- phototransduction
- single fertilization
Cellular Component
Where in the cell the gene product is active
- cation channel complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- calcium activated cation channel activity
- store-operated calcium channel activity
- protein binding
- metal ion binding
- calcium channel activity
- inositol 1,4,5 trisphosphate binding