Pcyox1 Gene Summary [Mouse]
Enables prenylcysteine oxidase activity. Acts upstream of or within prenylcysteine catabolic process. Located in lysosome. Is expressed in several structures, including genitourinary system; integumental system; limb; nervous system; and respiratory system. Orthologous to human PCYOX1 (prenylcysteine oxidase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pcyox1 |
| Official Name | prenylcysteine oxidase 1 [Source:MGI Symbol;Acc:MGI:1914131] |
| Ensembl ID | ENSMUSG00000029998 |
| Bio databases IDs | |
| Aliases | prenylcysteine oxidase 1 |
| Synonyms | 1200015P13Rik, Clp55, KIAA0908, PCL1, Pcly, prenylcysteine oxidase 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pcyox1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- FAD binding
- prenylcysteine lyase
- prenylcysteine oxidase
- NAD(P)-binding Rossmann-like domain
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the Pcyox1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- anaplastic thyroid cancer
- anaplastic thyroid carcinoma
- COVID-19
- papillary thyroid carcinoma
- epithelial thyroid cancer
- papillary thyroid cancer
regulates
- En2
- chloride
- L-cysteine
- geranylgeranylcysteine
- S-farnesylcysteine
role in cell
- contact growth inhibition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- lysosome
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pcyox1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- prenylated protein catabolic process
- prenylcysteine catabolic process
Cellular Component
Where in the cell the gene product is active
- very-low-density lipoprotein particle
- extracellular vesicular exosome
- lysosome
Molecular Function
What the gene product does at the molecular level
- FAD binding
- protein binding
- prenylcysteine oxidase activity