Arhgef11 Gene Summary [Mouse]
Predicted to enable G protein-coupled receptor binding activity and guanyl-nucleotide exchange factor activity. Predicted to be involved in several processes, including Rho protein signal transduction; positive regulation of DNA-templated transcription; and positive regulation of L-glutamate import across plasma membrane. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including cardiovascular system; cochlea epithelium; genitourinary system; gut; and nervous system. Orthologous to human ARHGEF11 (Rho guanine nucleotide exchange factor 11). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Arhgef11 |
| Official Name | Rho guanine nucleotide exchange factor (GEF) 11 [Source:MGI Symbol;Acc:MGI:2441869] |
| Ensembl ID | ENSMUSG00000041977 |
| Bio databases IDs | |
| Aliases | Rho guanine nucleotide exchange factor (GEF) 11 |
| Synonyms | GTRAP48, KIAA0380, mKIAA0380, PDZ-RHOGEF, Prg, RhoGEF, Rho guanine nucleotide exchange factor 11 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Arhgef11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Lsc-homology domain
- Domain present in PSD-95, Dlg, and ZO-1/2
- Regulator of G protein signalling-like domain
- G-protein-coupled receptor binding
- canonical PDZ domain
- Regulator of G protein signaling (RGS) domain superfamily
- protein binding
- Pleckstrin homology-like domain
- PDZ domain
- proline rich domain
- RhoGEF domain
- Regulator of G protein signaling domain
- RhoGEF
- guanyl-nucleotide exchange factor
- PH domain
- PDZ binding motif
- Dbl homology domain
Pathways
Biological processes and signaling networks where the Arhgef11 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- liver cancer
- pervasive developmental disorder
- obesity
- hepatocellular carcinoma
- thrombocytopenia
- hyperactive behavior
role in cell
- activation in
- formation
- binding in
- phosphorylation in
- colony formation
- proliferation
- invasion by
- migration
- number
- outgrowth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Nucleus
- Plasma Membrane
- cytosol
- nucleoplasm
- neurites
- nerve ending
- cellular protrusions
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Arhgef11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- positive regulation of transcription, DNA-dependent
- regulation of small GTPase mediated signal transduction
- regulation of cell growth
- establishment of cell polarity
- Rho protein signal transduction
- striated muscle contraction
- actin cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor binding
- protein binding
- guanyl-nucleotide exchange factor activity
- GTPase activator activity