Lman2l Gene Summary [Mouse]
Predicted to enable D-mannose binding activity. Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport and protein transport. Predicted to be located in Golgi apparatus. Predicted to be active in several cellular components, including COPII-coated ER to Golgi transport vesicle; Golgi membrane; and endoplasmic reticulum-Golgi intermediate compartment. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 69 and autosomal recessive intellectual developmental disorder 52. Orthologous to human LMAN2L (lectin, mannose binding 2 like). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lman2l |
| Official Name | lectin, mannose-binding 2-like [Source:MGI Symbol;Acc:MGI:2443010] |
| Ensembl ID | ENSMUSG00000001143 |
| Bio databases IDs | |
| Aliases | lectin, mannose-binding 2-like |
| Synonyms | A630028F14Rik, lectin, mannose-binding 2-like, LOC120094667, MRD69, MRT52, VIP36-like, VIPL |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lman2l often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Bacterial lectin
- legume lectins
- protein binding
- mannose binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- bipolar disorder
- autosomal recessive mental retardation
- renal clear cell adenocarcinoma
- renal clear cell cancer
- autosomal recessive mental retardation type 52
- autosomal dominant intellectual developmental disorder type 69
regulates
- glycoprotein
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Golgi Apparatus
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lman2l gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ER to Golgi vesicle-mediated transport
- protein transport
- protein folding
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- Golgi membrane
- Golgi apparatus
- ER to Golgi transport vesicle
- endoplasmic reticulum-Golgi intermediate compartment
Molecular Function
What the gene product does at the molecular level
- mannose binding
- protein binding
- metal ion binding