Ak2 Gene Summary [Mouse]
Predicted to enable adenylate kinase activity. Predicted to contribute to nucleobase-containing compound kinase activity. Predicted to be involved in ADP biosynthetic process; AMP metabolic process; and dATP metabolic process. Located in sperm mitochondrial sheath. Is expressed in several structures, including alimentary system; brain; genitourinary system; musculoskeletal system; and sensory organ. Human ortholog(s) of this gene implicated in reticular dysgenesis. Orthologous to human AK2 (adenylate kinase 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Ak2 |
| Official Name | adenylate kinase 2 [Source:MGI Symbol;Acc:MGI:87978] |
| Ensembl ID | ENSMUSG00000028792 |
| Bio databases IDs | |
| Aliases | adenylate kinase 2 |
| Synonyms | adenylate kinase 2, ADK2, D4Ertd220e |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ak2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- nucleobase, nucleoside, nucleotide kinase
- adenylate kinase
- NK
- adenylate kinase, isozyme 1 subfamily
- UMP-CMP kinase family
- protein binding
- AAA domain
- Adenylate kinase, active site lid
Pathways
Biological processes and signaling networks where the Ak2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- glioblastoma cancer
- glioma formation
- reticular dysgenesis
- hepatocellular carcinoma
- liver cancer
- severe combined immunodeficiency
- low-grade glioma
- nicotine dependence
- glioblastoma
role in cell
- proliferation
- growth
- phosphorylation in
- migration
- colony formation by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Mitochondria
- mitochondrial intermembrane space
- sperm tail
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ak2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ADP biosynthetic process
- AMP metabolic process
- ATP metabolic process
- nucleobase-containing small molecule interconversion
- nucleoside monophosphate phosphorylation
Cellular Component
Where in the cell the gene product is active
- mitochondrial intermembrane space
- extracellular vesicular exosome
- cytoplasm
- sperm mitochondrial sheath
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- ATP binding
- adenylate kinase activity
- protein binding