Moxd1 Gene Summary [Mouse]
Predicted to enable copper ion binding activity and dopamine beta-monooxygenase activity. Predicted to be involved in dopamine catabolic process; norepinephrine biosynthetic process; and octopamine biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in extracellular space and secretory granule membrane. Is expressed in several structures, including brain; exocrine gland; genitourinary system; respiratory system; and sensory organ. Orthologous to human MOXD1 (monooxygenase DBH like 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Moxd1 |
| Official Name | monooxygenase, DBH-like 1 [Source:MGI Symbol;Acc:MGI:1921582] |
| Ensembl ID | ENSMUSG00000020000 |
| Bio databases IDs | |
| Aliases | monooxygenase, DBH-like 1 |
| Synonyms | 3230402N08Rik, dJ248E1.1, MNCb-5203, monooxygenase DBH like 1, monooxygenase, DBH-like 1, MOX, PRO5780 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Moxd1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Copper type II ascorbate-dependent monooxygenase, C-terminal domain
- Domon-like ligand-binding domains
- DOMON domain
- Copper type II ascorbate-dependent monooxygenase, N-terminal domain
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetic nephropathy
- organismal death
- idiopathic pulmonary fibrosis
- uterine serous papillary cancer
- HER2 negative hormone receptor negative breast cancer
- autosomal dominant nocturnal frontal lobe epilepsy
role in cell
- proliferation
- apoptosis
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- nuclear fraction
- membrane fraction
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Moxd1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- dopamine catabolic process
- norepinephrine biosynthetic process
- octopamine biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- secretory granule membrane
- extracellular space
Molecular Function
What the gene product does at the molecular level
- protein binding
- copper ion binding
- dopamine beta-monooxygenase activity