Tnip2 Gene Summary [Mouse]
Predicted to enable polyubiquitin modification-dependent protein binding activity and protein kinase binding activity. Involved in several processes, including cell surface receptor signaling pathway; pattern recognition receptor signaling pathway; and positive regulation of leukocyte activation. Acts upstream of or within negative regulation of canonical NF-kappaB signal transduction. Is active in cytoplasm. Orthologous to human TNIP2 (TNFAIP3 interacting protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tnip2 |
| Official Name | TNFAIP3 interacting protein 2 [Source:MGI Symbol;Acc:MGI:2386643] |
| Ensembl ID | ENSMUSG00000059866 |
| Bio databases IDs | |
| Aliases | TNFAIP3 interacting protein 2 |
| Synonyms | 1810020H16RIK, ABIN-2, FLIP1, KLIP, TNFAIP3 interacting protein 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tnip2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase binding
- UBAN motif
- Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
- TSG101 and ALIX binding domain of CEP55
- protein binding
- zinc finger domain
Pathways
Biological processes and signaling networks where the Tnip2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic lupus erythematosus
- B-cell non-Hodgkin disease
- mature B-cell neoplasia
- airway inflammation
- diffuse large B-cell lymphoma
role in cell
- cell viability
- apoptosis
- generation in
- activation in
- activation
- survival
- autophosphorylation in
- function
- response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tnip2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- toll-like receptor 9 signaling pathway
- toll-like receptor 2 signaling pathway
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
- CD40 signaling pathway
- inflammatory response
- positive regulation of B cell activation
- cellular response to lipopolysaccharide
- positive regulation of macrophage activation
- apoptotic process
- toll-like receptor 3 signaling pathway
- interleukin-1-mediated signaling pathway
- negative regulation of endothelial cell apoptotic process
- protein stabilization
Cellular Component
Where in the cell the gene product is active
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- polyubiquitin binding
- K63-linked polyubiquitin binding
- metal ion binding