Supv3l1 Gene Summary [Mouse]
Predicted to enable several functions, including double-stranded RNA binding activity; helicase activity; and protein homodimerization activity. Predicted to be involved in several processes, including mitochondrial RNA 3'-end processing; mitochondrial RNA surveillance; and positive regulation of mitochondrial RNA catabolic process. Located in mitochondrion. Is expressed in several structures, including brain; early embryo; extraembryonic component; sensory organ; and skin. Orthologous to human SUPV3L1 (Suv3 like RNA helicase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Supv3l1 |
| Official Name | suppressor of var1, 3-like 1 (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:2441711] |
| Ensembl ID | ENSMUSG00000020079 |
| Bio databases IDs | |
| Aliases | suppressor of var1, 3-like 1 (S. cerevisiae) |
| Synonyms | 6330443E10Rik, suppressor of var1, 3-like 1 (S. cerevisiae), SUV3, Suv3 like RNA helicase |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Supv3l1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- helicase
- helicase superfamily c-terminal domain
- enzyme
- protein binding
- identical protein binding
- Helicase conserved C-terminal domain
- RNA helicase
- DNA binding
- DNA helicase
- RNA binding
- Suv3 helical N-terminal domain
- double-stranded RNA binding
- Suv3 C-terminal domain 1
- N-terminal helicase domain of the DEAD-box helicase superfamily
- protein homodimerization
- DEAD-like helicases superfamily
- P-loop containing Nucleoside Triphosphate Hydrolases
- Mitochondrial degradasome RNA helicase subunit C terminal
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- mammary neoplasm
- lung adenocarcinoma
- lung adenocarcinoma formation
- growth failure
- lung squamous cell carcinoma
- squamous cell lung cancer
regulates
- mitochondrial DNA
- dsRNA
role in cell
- apoptosis
- growth
- autophagy in
- accumulation in
- organization
- autophagy
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Mitochondria
- mitochondrial matrix
- mitochondrial nucleoids
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Supv3l1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitochondrial mRNA catabolic process
- mitochondrial RNA catabolic process
- DNA recombination
- mitochondrial RNA 3'-end processing
- positive regulation of mitochondrial RNA catabolic process
- mitochondrion organization
- RNA catabolic process
- mitochondrial RNA surveillance
- positive regulation of cell growth
- negative regulation of apoptotic process
- DNA duplex unwinding
- mitochondrial ncRNA surveillance
- mitochondrial mRNA surveillance
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrial matrix
- mitochondrion
- mitochondrial degradosome
- mitochondrial nucleoid
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- identical protein binding
- protein homodimerization activity
- helicase activity
- DNA binding
- ATP binding
- DNA helicase activity
- protein binding
- RNA binding
- RNA helicase activity
- double-stranded RNA binding
- 3'-5' RNA helicase activity