Wwox Gene Summary [Mouse]
Enables enzyme binding activity. Contributes to transcription coactivator activity. Involved in cellular response to transforming growth factor beta stimulus; positive regulation of extrinsic apoptotic signaling pathway; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including apoptotic signaling pathway; osteoblast differentiation; and positive regulation of extrinsic apoptotic signaling pathway in absence of ligand. Located in mitochondrion and nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including adrenal gland; central nervous system; genitourinary system; hemolymphoid system gland; and skeleton. Used to study autosomal recessive spinocerebellar ataxia 12. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 12; developmental and epileptic encephalopathy 28; esophagus squamous cell carcinoma; and squamous cell carcinoma. Orthologous to human WWOX (WW domain containing oxidoreductase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Wwox |
| Official Name | WW domain-containing oxidoreductase [Source:MGI Symbol;Acc:MGI:1931237] |
| Ensembl ID | ENSMUSG00000004637 |
| Bio databases IDs | |
| Aliases | WW domain-containing oxidoreductase |
| Synonyms | 5330426P09Rik, 9030416C10Rik, D16S432E, DEE28, EIEE28, FOR, FRA16D, HHCMA56, PRO0128, SCAR12, SDR41C1, WOX1, WW domain-containing oxidoreductase |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Wwox often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- Domain with 2 conserved Trp (W) residues
- transcription co-activator
- WW
- enzyme binding
- enzyme
- protein binding
- short chain dehydrogenase
- short chain dehydrogenase/reductase domain
- identical protein binding
- WW domain
- ADH domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic obstructive pulmonary disease
- squamous cell lung cancer
- gastrointestinal neoplasia
- epithelial neoplasia
- epithelial cancer
- cancer
- digestive system cancer
- neoplasia
- esophageal squamous cell cancer
- esophageal carcinoma formation
phenotypes
- Leydig cell hyperplasia
- Leydig cell hypoplasia
- abnormal circulating enzyme level
- abnormal compact bone morphology
- abnormal homeostasis
- abnormal osteoblast differentiation
- abnormal osteoclast physiology
- abnormal pituitary gland physiology
- abnormal primary ovarian follicle morphology
- abnormal skeleton development
- abnormal skeleton morphology
- abnormal thymus cortex morphology
- abnormal trabecular bone morphology
- anemia
- cachexia
- decreased body size
- decreased body weight
- decreased bone mineral density
- decreased bone trabecula number
- decreased circulating alkaline phosphatase level
- decreased circulating aspartate transaminase level
- decreased circulating bicarbonate level
- decreased circulating calcium level
- decreased circulating chloride level
- decreased circulating cholesterol level
- decreased circulating glucose level
- decreased circulating serum albumin level
- decreased circulating sodium level
- decreased circulating testosterone level
- decreased circulating total protein level
- decreased circulating triglyceride level
- decreased compact bone area
- decreased compact bone thickness
- decreased leukocyte cell number
- decreased liver weight
- decreased osteoblast cell number
- decreased spleen weight
- decreased survivor rate
- decreased theca cell number
- decreased thymus weight
- decreased trabecular bone connectivity density
- decreased trabecular bone thickness
- decreased trabecular bone volume
- enlarged spleen
- hypoglycemia
- increased B cell derived lymphoma incidence
- increased adrenal gland weight
- increased blood urea nitrogen level
- increased blood uric acid level
- increased bone resorption
- increased brain weight
- increased circulating bilirubin level
- increased circulating chloride level
- increased circulating phosphate level
- increased circulating potassium level
- increased incidence of tumors by chemical induction
- increased lung tumor incidence
- increased malignant tumor incidence
- increased osteosarcoma incidence
- increased pituitary gland weight
- increased skeletal tumor incidence
- increased tumor incidence
- postnatal growth retardation
- postnatal lethality complete penetrance
- premature death
- reduced male fertility
- seminiferous tubule degeneration
- small ovary
- small seminiferous tubules
- small spleen
- small testis
- spleen atrophy
- testicular atrophy
- testis hypoplasia
- thin uterine horn
role in cell
- apoptosis
- colony formation
- survival
- migration
- expression in
- activation in
- phosphorylation in
- proliferation
- growth
- invasion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell surface
- perinuclear region
- Nucleus
- Plasma Membrane
- Golgi Apparatus
- Mitochondria
- cytosol
- perinuclear vesicles
- microvilli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Wwox gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to transforming growth factor beta stimulus
- positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
- signal transduction by p53 class mediator resulting in induction of apoptosis
- extrinsic apoptotic signaling pathway
- osteoblast differentiation
- Wnt receptor signaling pathway
- negative regulation of Wnt receptor signaling pathway
- positive regulation of extrinsic apoptotic signaling pathway
- positive regulation of transcription from RNA polymerase II promoter
- skeletal system morphogenesis
Cellular Component
Where in the cell the gene product is active
- nucleus
- microvillus
- cytoplasm
- mitochondrion
- cytosol
- Golgi apparatus
- plasma membrane
- lysosome
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription coactivator activity
- oxidoreductase activity
- enzyme binding