Aifm2 Gene Summary [Mouse]
Predicted to enable several functions, including electron-transferring-flavoprotein dehydrogenase activity; flavin adenine dinucleotide binding activity; and oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor. Involved in regulation of cellular response to oxidative stress. Located in mitochondrial membrane and nucleus. Is expressed in adrenal medulla; central nervous system; and retina. Orthologous to human AIFM2 (AIF family member 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Aifm2 |
| Official Name | apoptosis-inducing factor, mitochondrion-associated 2 [Source:MGI Symbol;Acc:MGI:1918611] |
| Ensembl ID | ENSMUSG00000020085 |
| Bio databases IDs | |
| Aliases | apoptosis-inducing factor, mitochondrion-associated 2 |
| Synonyms | 5430437E11Rik, AIF family member 2, AMID, apoptosis-inducing factor, mitochondrion-associated 2, D730001I10Rik, FLJ14497, FSP1, PRG3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Aifm2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- flavin adenine dinucleotide binding
- electron-transferring-flavoprotein dehydrogenase
- Pyridine nucleotide-disulphide oxidoreductase
- enzyme
- protein binding
- DNA binding
- NADH or NADPH:quinone oxidoreductase
Pathways
Biological processes and signaling networks where the Aifm2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- organismal death
- metastasis
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- rheumatoid arthritis
- epithelial neoplasia
- breast cancer
role in cell
- expression in
- apoptosis
- cell death
- cell viability
- migration
- acetylation in
- proliferation
- ferroptosis
- biogenesis
- biogenesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Plasma Membrane
- Mitochondria
- lipid droplets
- cytosol
- mitochondrial membrane
- mitochondrial outer membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Aifm2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cellular response to oxidative stress
- apoptotic mitochondrial changes
- positive regulation of apoptotic process
- respiratory electron transport chain
- vitamin K metabolic process
- ubiquinone metabolic process
Cellular Component
Where in the cell the gene product is active
- lipid particle
- nucleus
- extracellular space
- cytoplasm
- mitochondrion
- cytosol
- mitochondrial outer membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- flavin adenine dinucleotide binding
- electron-transferring-flavoprotein dehydrogenase activity
- oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor