Wdfy4 Gene Summary [Mouse]
Acts upstream of or within with a positive effect on CD8-positive, alpha-beta T cell activation. Acts upstream of or within antigen processing and presentation and cellular response to virus. Predicted to be located in early endosome and endoplasmic reticulum. Orthologous to human WDFY4 (WDFY family member 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Wdfy4 |
| Official Name | WD repeat and FYVE domain containing 4 [Source:MGI Symbol;Acc:MGI:3584510] |
| Ensembl ID | ENSMUSG00000051506 |
| Bio databases IDs | |
| Aliases | WD repeat and FYVE domain containing 4 |
| Synonyms | C10orf64, Gm18810, RGD1564142, WDFY family member 4, WD repeat and FYVE domain containing 4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Wdfy4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- WD40 repeats
- WD domain, G-beta repeat
- protein binding
- Pleckstrin homology-like domain
- Beach
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic lupus erythematosus
- inflammatory bowel disease
- splenomegaly
- idiopathic scoliosis
- rheumatoid arthritis
- psychosis
- stroke
- ulcerative colitis
- primary biliary cirrhosis
- diabetes mellitus
role in cell
- number
- activation
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Wdfy4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- CD8-positive, alpha-beta T cell activation
- autophagy
- antigen processing and presentation
Cellular Component
Where in the cell the gene product is active
- early endosome
- endoplasmic reticulum