Srgap1 Gene Summary [Mouse]
Enables GTPase activator activity and small GTPase binding activity. Acts upstream of or within Rho protein signal transduction and cell migration. Predicted to be active in cytoplasm. Is expressed in mesonephros mesenchyme; metanephros; nervous system; neural retina; and vomeronasal organ. Used to study focal segmental glomerulosclerosis. Human ortholog(s) of this gene implicated in papillary thyroid carcinoma. Orthologous to human SRGAP1 (SLIT-ROBO Rho GTPase activating protein 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Srgap1 |
| Official Name | SLIT-ROBO Rho GTPase activating protein 1 [Source:MGI Symbol;Acc:MGI:2152936] |
| Ensembl ID | ENSMUSG00000020121 |
| Bio databases IDs | |
| Aliases | SLIT-ROBO Rho GTPase activating protein 1 |
| Synonyms | 4930572H05Rik, ARHGAP13, NMTC2, RGD1566260, SLIT-ROBO Rho GTPase activating protein 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Srgap1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RhoGAP domain
- enzyme binding
- Fes/CIP4, and EFC/F-BAR homology domain
- GTPase activator
- protein binding
- GTPase Activating Protein domain
- GTPase-activator protein for Rho-like GTPases
- RhoGAP
- Bin/Amphiphysin/Rvs domain
- Src Homology 3 domain superfamily
Pathways
Biological processes and signaling networks where the Srgap1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gastric cancer
- colorectal cancer
- idiopathic scoliosis
- splenomegaly
- ovarian carcinoma
- epithelial ovarian cancer
- pancreatic carcinoma
- pancreatic epithelial cancer
- nonmedullary thyroid cancer type 2
- congenital anomalies of kidney and urinary tract
role in cell
- expression in
- proliferation
- invasion by
- migration
- formation
- formation in
- differentiation
- colony formation
- outgrowth
- outgrowth in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Srgap1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- negative regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- GTPase activator activity